Autoimmune progesterone dermatitis (APD) is a circumstance in which the menstrual rhythm is associated with an amount of rind findings such as urticaria, eczema, angioedema, and others. The circumstance presents with a kind of rind eruptions characterized by cyclical recurrent premenstrual exacerbations payable to progesterone variation during the menstrual rhythm. Autoimmune progesterone dermatitis usually presents during early adult life, and the disease may periodically go into spontaneous remission. Exogenous progesterone (eg, in oral contraceptives containing progestational agents like norethindrone or synthetic progestogens like norgestrel or levonorgestrel) may aggravate the skin eruptions of autoimmune progesterone dermatitis. Some women with chronic urticaria experience cyclical exacerbations of their skin condition corresponding with the menstrual cycle, and it is possible that progesterone plays a role in this process.

Severity of symptoms can change from almost imperceptible to anaphylactic in nature, and symptoms can be liberal. There are no particular histological features on biopsy in autoimmune progesterone dermatitis. The age of onslaught is varying, with the earliest age reported at menarche. The symptoms of APD correlate with progesterone levels during the luteal phase of the menstrual cycle. Symptoms may first appear, improve, or worsen during pregnancy and the peripartum period. In addition, autoimmune progesterone dermatitis during pregnancy has been associated with spontaneous abortions. This disease may become worse during pregnancy. Autoimmune progesterone dermatitis must be differentiated from perimenstrual flares of skin diseases such as acne, dermatitis herpetiformis, erythema multiforme, lichen planus, lupus erythematosus, psoriasis and estrogen dermatitis.

The diagnosis of Autoimmune progesterone dermatitis requires a proper clinical story accompanied by an intradermal injection examination with progesterone. Autoimmune progesterone dermatitis is normally impervious to traditional therapy such as antihistamines. The use of systemic glucocorticoids, usually in high doses, has been reported to control the cutaneous lesions of APD is some studies, but not in others. Oral contraceptives are often tried as initial therapy, but have had limited success, possibly due to the fact that virtually all oral contraceptives have a progesterone component. Conjugated estrogens have also been used in the treatment of autoimmune progesterone dermatitis. Tamoxifen, a nonsteroidal antiestrogen agent, may be effective in some patients but may cause amenorrhea. In some cases, the eruptions often settle spontaneously after a period of successful treatment.


19 thoughts on “Complete Information On Autoimmune Progesterone Dermatitis With Treatment And Prevention

  1. Brittany

    im worried i might be PREGOOO?
    Hi im brittany and im 17. i am starting to wonder if i am pregnant. i have had many scares in the past year and a half or so but there is something different this time. i was on birth control for a while off and on and my periods have never been on time. the last scare i had was 5 months without a period and something came out of me that was discolored. i thought it had been a miscarriage because the pain was so bad i couldn’t move and i just laid there with a heating pad and cried for a few days straight and was bleeding like a mad cow. my ob/gyn said it was built up tissue and told me to continue on with my birth control that she had given me a month before to make my period happen because i had a negative pregnancy test. Lupus runs in the family which makes false readings on many things such as pregnancy tests. my mom has recently told me this and that me and my brother both were false readings and she didn’t know she was pregnant until she was a little over 3 months prego. to get to the point i stopped taking the birth control prescibed to me because i had a heavy flow of periods for 2 weeks at a time and wouldnt barely bleed for 2 days and then another 2 weeks or so of bleeding for 3 months, so i stopped taking the birth control around the 1st of july. the end of my period was around the 6th of july. i think i was having the ovulating pain around the 21st of july. around july 31st to august 5th i was spotting light brownish blood. it was not a normal at all. it was off and on between the 31st and the 5th. around that time is when i started sleeping all day everyday. i wanted to get up and do stuff but i was naucious and just so tired. since then, i have been sleeping non stop and i get very naucious every day, especially after i eat. my lower back is killlling me and my abdomen is bloated a little bit. the weird thing is, right under my belly button where its bigger, it feels hard. not really hard, just not normally how it feels. please give me advice…sorry i wrote so much, thought that the whole story should be known.

    i have taken many prego tests, and have done matress mambo, unprotected, more than 10 times in july and same with august

  2. eiseisbaby07

    Does anyone have some kind words for nervous TTC….?
    MY friend at work is just starting on TTC in January. She is 26 and her hubby is 33 she has Lupus but it is controlled and she has been cleared by the doctor!! All her meds are under control and the docs say everything is healthy and in perfect condition to conceive! But she is nervous that she may not be able to conceive or having a miscarriage and all that stuff that comes along with trying to get pregnant. I just wanted to hear ALL of your stories about how long it took you to conceive, your age when TTC, and how the pregnancy and everything went.!! It only took me 2 weeks to conceive so I’m not a big help for her and she needs a vote of CONFIDENCE ladies!!!!! Thnks!!

    1. Jellybean had her little bean

      HIDY- I don’t think that’s what she was asking, she’s looking for something positive!!!

      I am TTC so I feel for your friend. Tell her not to worry because stress isn’t good when she does get pregnant. Good Luck to her!!!

      {{{{{ well wishes}}}}}

  3. IamHisBaby

    Lots of signs & symptoms of pregnancy but negative tests… I’m totally confused?
    I am a very small girl… I weigh 100 lbs and have always worn a size 1 in pants with a washboard stomach. I have never been able to grow my fingernails no matter what I tried. I’ve had thin hair that shedded alot too. For the past 4 years, I have had a strange GYN illness that no doctors have really been able to really diagnose. Possibilities have been endometriosis, Lupus & have gone back and forth and they had me on continuous birth control but did some changes between the Deop shot and pills but there was also some antibiotics given to me during the same time.
    Now… everything within myself tells me I am pregnant. Its just not me, family members and friends who have known me & my illness for years convinced and baffled by the negative pregnancy results too. As best as I can figure… I think that I would be somewhere between 8-12 weeks pregnant if I am. Here are my symptoms:
    ~ I have a small baby bump (where just a few weeks ago was a washboard stomach)
    ~ My fingernails are growing like crazy and are practically unbreakable! Something that I have never been able to do is grow nails at all!
    ~ My hair has grown about 4-5 inches in the past 2 months and has gotten alot thicker. Plus, I have practically no hair at all coming out when I wash my hair or brush my hair.
    ~ I am having extreme fatigue all the time… I can’t shake this tired feeling.
    ~ I am staying nausiated all the time.
    ~ Foods don’t taste good or even the same to me at all. My tastes seem to be off with almost everything.
    ~ I have worn a size 1 in pants for years with no change but in the last couple of weeks my clothes aren’t fitting anymore. A size 3 is totally tight and uncomfortable… the other day I was wearing a pair of my cousins size 7’s that were even kinda tight.
    ~ I have had some light cramping like twinges but nothing alarming or painful in my stomach.
    BECAUSE… of the continuous birth control however, I don’t have periods anymore so that isn’t a symptom that I have to judge from.
    Although, I know the science and the claims of the medical community about the accuracy of pregnancy tests both urine & blood based on Hcg levels but I have also read blogs from people about blood tests being negative while people are actually pregnant. As well, as people who became pregnant while on Depo but then again on the flip side people on Deop not being able to get pregnant.
    All I know is that something isn’t right and none of this makes any sense for me whatsoever… if I’m not pregnant.
    If anyone has any stories or experiences that relate to what I am going through I would really be interested to hear about them. I am beginning to wonder if I do have endometriosis… if this condition could somehow hormonally interfer with the results of the pregnancy tests.
    I hope someone can offer some helpful information or advice for me here.

  4. Anonymous

    There’s a bunch of people out there who variously believe that HIV does not cause AIDS, or that AIDS does not exist, or that HIV is not sexually transmitted. They have been well and truly refuted on all counts.

    They make pests of themselves by spamming various websites and bulletin boards with long copy and paste posts, mostly taken from two or three AIDS denialist websites. They attacked Yahoo answers for a few months last year. It looks like they’re still spamming boards with the same stuff. The numbers in this post originally referred to footnotes, but the text has been copied and pasted so many times that the footnotes have disappeared from most versions.

    ————————————————————–

    It is true that false positive ELISA tests for HIV occur – about 3 in 1000 tests give a false positive. The list is of apparent causes for these false positives.

    Positive ELISA tests are always followed up by a confirmatory test – usually a Western Blot or similar. A diagnosis of HIV infection is only made if both tests are positive. The rate of false diagnoses using both tests together is extremely low.

    Negative ELISA tests by themselves, however, are quite reliable, so long as they are done after the window period (13 weeks).

  5. just me

    Anyone with SLE (lupus) during pregnancy?
    I have SLE and hypothyroidism and I’m pregnant. My OB just scared me so badly about miscarriage and other risks. Can anyone share with me your pregnancy stories, details on how you were treated during pregnancy, and if you were told to do/not do anything during pregnancy to increase your chance of a successful pregnancy? I’m not sure that my OB is really familiar enough with treating SLE patients and would like to make sure I’m also on top of things. Any information is appreciated. I’m stressed right out right now.

    1. Brandi K

      hey, well i don’t have lupus… but my best friend has it… during her pregnancy she just relaxed, didn’t work to much, and ate really healthy…the doctor told her to keep her feet up as much as possible…. her daughter is now 2 and very healthy!!

  6. Krisi

    Anti-Nuclear Antibodies… anyone with experience or knows anything about, please answer! :)?

    Hi, thanks for reading my question, now I’ll let you know a little more information. When I was 12/13 years old I went to a yearly eye doctor appointment where they saw blurriness and swelling behind the eye (really confusing I even have 20/20 vision) Anyways so I was refereed to MANY doctors ending with the possible chance of Lupus. I am now 19 years old and I still have a very high Antinuclear Antibody count and as of right now, NO lupus! 🙂 Well, I was watching a Baby Story on TLC (because I want to be a labor and delivery nurse) and heard that this lady has a very high ANA count and had trouble conceiving, 7 pregnancies, only 2 successful, 2 stillborn and the rest miscarriages. Here’s the deal I have been with my boyfriend for 3 years now, and although we are not planning on having children soon, it is something we really need to know more about. I am looking for anybody that has ANY experience in this, or even a little knowledge, I have looked online and it scares me half to death! Ha ha, it can always do that! Please and thank you…

    edit: I do have a doctors appointment for a routine check up and I will ask the Doc. this question but I am looking for a Little more insight, familiarities!

    1. New Mummy

      i dont know much about it but if this helps i was also tested for lupus and similar because of my ANA count (not normal levels apparently) and right now im pregnant with a healthy baby…
      sorry i cant help any more than that x

  7. Wolf Femme

    I have a strong connection with people I care about..?
    To the point where I feel what they feel.
    I had all of the symptoms of pregnancy a while ago. There was no way I was pregnant, though.
    I got my sister-in-law a box of pregnancy tests; negative.
    The next day, my cousin called to inform us that she was pregnant.
    Two weeks later I felt like shite, she called within the week to tell us she had a miscarriage.

    My father cut his finger to the bone many years back at work.
    Half an hour before my mum called to tell my brother and I to get around; my entire hand [and especially my ring finger] hurt like a b*tch.

    etc.

    Now; I have what I’d consider — strong feelings for this boy. We talk and hang out during the school day quite a lot.
    For the past month or two [which is when we’ve been getting closer], I’ve been getting headaches off and on. My eyesight seems to have blurred when I try to focus on things far away from me. I get dizzy and have problems walking at intervals during the day.
    My doctor has no idea what is causing the headaches, but he feels that my motor and visionary problems may be a result of the headache.
    I am otherwise in perfect health.

    Today I found out that the boy has been diagnosed with Lupus.
    I had no idea what that was until I came home and searched online.

    Not only do I feel completely crestfallen, and just want to take him into my arms and squeeze him; but I also feel the need to dull my own symptoms from the connections I get.
    I won’t sever my connections to my family and friends; but I don’t want to be going through the same exact thing that they’re going through.
    I’d much rather be able to access those problems to help them through; but always be able to hold their hands and wipe their eyes when needed; instead of needing it done for myself.

    Question:
    How can I keep the connections, but dull the symptom-connections?

    Also:
    If anyone has anything similar to these connections; it would really help me to hear your story or something.
    Thank you.

    1. Saved from TN

      Sorry, I can’t say I’ve ever experienced anything like you.
      The best I can tell you is to talk to someone or some sort of specialist.

      Sounds like a job for Gregory House. haha

  8. angel

    hereditary or coincidence?
    I work in the med field, and have asked this question, best I can get from doctors is “gee, I dunno, maybe.” So I’m asking opinions, and if anyone else has a similar story I’m interested in what you think…
    My mother is epileptic. Her seizures are triggered by stress, lack of sleep, or physical illness.
    All three of her children have auto immune issues. 1 sister has severe physical reactions to pregnancy. The theory we got from doctors is that her immune system goes on attack and treats the baby like a disease. Possibly its the hormone that triggers it.
    The other sister has lupus, also auto immune, moderate and manageable.
    And I have vitiligo. My immune system attacks pigment like a disease.
    My nephew has chronic severe migraines. We can’t find a cause. He also used to scream in his sleep and shake when he was a baby, so we suspected HE had epilepsy, too, but he’s never had a seizure and it stopped when he was about seven or eight. He also sleepwalks.
    And finally, my niece has severe juvenile arthritis. A month ago, she had an anaphylactic reaction to the smell of shrimp, and doctor says she now can not be around fish or shellfish at ALL. (She grew up on red lobster. No idea why, but I know allergies are unpredictable.)
    And finally, my youngest niece constantly catches colds, flu, pneumonia, ear infections. I mean if you sneeze twenty yards away on a windless day in july, she’ll get it. She also gets pretty severe eczema. She has a weak immune system.
    So here’s my question(s)-
    1. Are auto immune illnesses hereditary, or is my family an anomaly?
    2. Is it possible that all three of us were affected by moms epilepsy or by the meds she was using back then? (phenobarb, and something else that was commonly used in the 60s and 70s to treat epilepsy but was banned, can’t think of the name, so help with that too would be great.)
    3. If I were to have a child, is it pretty much guaranteed that something would be wrong with it?
    5150- no, we don’t live together, but we do all live in the same city. We don’t live in an area where we are exposed to any higher-than-average toxins. As far as I’ve been able to tell, there are not unusually high numbers in any of these illnesses in this area, either.

    1. Amanda

      There are studies that show that there CAN be a genetic link, but the sciences are inconclusive on it.

      2. It’s possible that the medication had an effect. My grandmother took medication for morning sickness and my mother and I BOTH have had endometriosis and autoimmune disorders after that. Before then, no one had endo.

      3. It’s not guaranteed, but I would be cautious just because it seems to be hereditary in yours even if science can’t prove it is.

  9. Krisi

    Anti-Nuclear Antibodies… anyone with experience or knows anything about, please answer! :)?
    Hi, thanks for reading my question, now I’ll let you know a little more information. When I was 12/13 years old I went to a yearly eye doctor appointment where they saw blurriness and swelling behind the eye (really confusing I even have 20/20 vision) Anyways so I was refereed to MANY doctors ending with the possible chance of Lupus. I am now 19 years old and I still have a very high Antinuclear Antibody count and as of right now, NO lupus! 🙂 Well, I was watching a Baby Story on TLC (because I want to be a labor and delivery nurse) and heard that this lady has a very high ANA count and had trouble conceiving, 7 pregnancies, only 2 successful, 2 stillborn and the rest miscarriages. Here’s the deal I have been with my boyfriend for 3 years now, and although we are not planning on having children soon, it is something we really need to know more about. I am looking for anybody that has ANY experience in this, or even a little knowledge, I have looked online and it scares me half to death! Ha ha, it can always do that! Please and thank you…

    edit: I do have a doctors appointment for a routine check up and I will ask the Doc. this question but I am looking for a Little more insight, familiarities!

    1. cajanass38000

      In two my pregnancy I had antibodies first pregnant my blood count was 60..then my 2 pregnancy my blood count was 80..This pregancy was very dangerous my doctor said i was a high risk..I had see specialist 100 mile away..and yeah the last pregnant scare me to dealth..If you have good specialist ob doctor you could be watch more careful then he could kept on eye on your blood count for antibodies. my son is mircale to me..I was at high risk.

  10. Skadoctor1

    I need good stories – any one had 3+ miscarriages, no live births without explanation and carry to term?
    I have had 4 miscarriages. My husband and I have been through all the tests: hystosalpingogram, chromosome, all the hormone blood tests (including antibody tests, lupus, etc), sperm count/test, ultrasounds, etc.

    I didnt ever show having cysts, every thing else came back within normal range. Ive heard that some times pregnancies are non-viable and women have 5,6,7+ miscarriages before a baby is made that goes to full term. My dr. said he’s had several women in his practice that have done such, unassisted. My question is….

    Has any one had similar as me and gone on to carry a healthy baby to term? Your personal story will help me at this time as I am loosing hope of being a mommy without an underlying cause of miscarriage (which has already been ruled out).

    The dr. has prescribed clomid and progesterone for me to begin taking next month. Said that might help since there arent any other factors going ‘wrong’. They did find a cyst, not attached to my uterus, this past month of ultrasounds. First cyst they have found in 6 years of testing. I go back in 6 weeks to see if its gone away on its own or, if I need surgery. They now think I might have a variable form of PCOS where I dont have the hormone issues or insulin resistance, but my ovaries hyperstimulate.

    Thanks (serious replys only).
    I got pregnant 6 mos. in to trying first pregnancy, a year after the miscarriage the 2nd, the next month for the 3rd, then waited 2 years and got pregnant 3 mos. in to trying 4th pregnancy. Waited almost 8 mos. and have been ttc 3 mos., this month.

    Why does metformin help? my dr. wont give it to me because I havent been shown to have insulin resistance w/ blood tests.

  11. Brittany

    i think i might be pregnant?
    Hi im brittany and im 17. i am starting to wonder if i am pregnant. i have had many scares in the past year and a half or so but there is something different this time. i was on birth control for a while off and on and my periods have never been on time. the last scare i had was 5 months without a period and something came out of me that was discolored. i thought it had been a miscarriage because the pain was so bad i couldn’t move and i just laid there with a heating pad and cried for a few days straight and was bleeding like a mad cow. my ob/gyn said it was built up tissue and told me to continue on with my birth control that she had given me a month before to make my period happen because i had a negative pregnancy test. Lupus runs in the family which makes false readings on many things such as pregnancy tests. my mom has recently told me this and that me and my brother both were false readings and she didn’t know she was pregnant until she was a little over 3 months prego. to get to the point i stopped taking the birth control prescibed to me because i had a heavy flow of periods for 2 weeks at a time and wouldnt barely bleed for 2 days and then another 2 weeks or so of bleeding for 3 months, so i stopped taking the birth control around the 1st of july. the end of my period was around the 6th of july. i think i was having the ovulating pain around the 21st of july. around july 31st to august 5th i was spotting light brownish blood. it was not a normal at all. it was off and on between the 31st and the 5th. around that time is when i started sleeping all day everyday. i wanted to get up and do stuff but i was naucious and just so tired. since then, i have been sleeping non stop and i get very naucious every day, especially after i eat. my lower back is killlling me and my abdomen is bloated a little bit. the weird thing is, right under my belly button where its bigger, it feels hard. not really hard, just not normally how it feels. please give me advice…sorry i wrote so much, thought that the whole story should be known.
    i have taken many prego tests, and have done matress mambo, unprotected, more than 10 times in july and same with august.

    1. computer_saskboy

      Hi Brittany,
      I think you should see another doctor soon, for a second opinion of what is happening to you, and so they give you something other than birth control pills that aren’t working to help with the pain, tiredness, and sick feeling when you eat. It could be the type of foods that you’re eating. You could try an elimination diet, to see if that improves anything, in case you have an allergy or sensitivity to something. Tell the doctor that your abdomen doesn’t feel normal — that doesn’t mean you’re pregnant, but it means your other doctor should be testing you until they find out what is wrong.

      Since you’ve had unprotected sex, and a lot of it, it’s quite possible you’re pregnant, or miscarrying. The negative pregnancy test seems to say not, unless your mother is right, and the doctor didn’t know about that family history.

      If you don’t want to have a baby at 18, start using condoms too, don’t rely on your birth control if you keep having “scares”. Good luck.

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