Kikuchi disease is rare condition. Kikuchi’s disease, also called as histiocytic necrotizing lymphadenopathy. Kikuchi’s illness is an infection or autoimmune disorder. It affects people of all national backgrounds, although it seems to influence women about 3 times more frequent than men. Kikuchi disease has been reported throughout the world and in all races. Only remote cases are reported in Europe. Kikuchi’s disease is a self limiting illness which has very likely symptoms to Hodgkin’s lymphoma. Kikuchi disease occurs in a broad age range, but generally affects young adults.

Kikuchi disease is frequent mistaken for malignant lymphoma, especially cervical adenopathy because the symptoms are very similar.  Kikuchi disease usually takes the type of lymph node inflammation. The lymph nodes on one or both sides of the neck are usually affected. Most of the time these are the only lymph nodes affected. The lymph nodes are painless, hard, and around 2-3 cm in diameter. A fever and flu-like symptoms develop. In up to 30% of individuals, a red rash may seem. Kikuchi disease can also imitate Systemic lupus erythematosus(SLE).

Both can near with lymphadenopathy and fever, and the cutaneous findings seen in 30% of Kikuchi disease patients can look like those seen in SLE. In Kikuchi disease, antinuclear antibodies (ANA), rheumatoid factor (RF), and lupus erythematosus (LE) preparations are usually, although not always, negative. Kikuchi disease and SLE can also have similar histopathologic appearances. Kikuchi disease is recommended by the absence or lack of the hematoxylin bodies, plasma cells, and neutrophils usually seen in SLE. Additionally, T lymphocytes predominate in Kikuchi disease, whereas B lymphocytes predominate in SLE.

Kikuchi’s disease has been information to be related with infections of Epstein-Barr virus, human herpesvirus 6, toxoplasmosis, and Human T-lymphotropic virus 1. Treatment of Kikuchi disease is usually helpful. The aims of pharmacotherapy are to decrease morbidity and to prevent complications. Nonsteroidal anti-inflammatory drugs (NSAIDs) may be employed to improve lymph node tenderness and fever. The use of corticosteroids, such as prednisone, has been recommended in severe more nodal or generalized Kikuchi disease. Kikuchi disease will resolve on its own usually within 1-6 months. Antibiotics are not required.

6 thoughts on “Cutaneous Lupus Disease

  1. just a daydream away

    Could stretch marks be a symptom of something?
    This probably sounds stupid, but I just want a clarification.
    Three years ago, I got sick and started gaining a lot of weight (which is the probable cause of the stretch marks), but I have a lot of them, and they’re dark… I’m fifteen. I have a lupus-like autoimmune disease, idiopathic thrombocytopenia purpura (ITP), and cutaneous lupus. I don’t know if any of those would cause increasing stretch marks.. Do any autoimmune diseases cause things like this, or any other disease for that matter?
    Thanks for obviously pointing out the fact that I’m fat.
    Next time read the details of my question and answer according to what it says. You missed some pretty important details. Okay thanks.

    1. Linda R

      Cutaneous lupus may make you more likely to develop stretch marks but it does not cause them. If you were on steroids, that could also have increased the likelihood of developing stretch marks.

  2. Katie E

    Lupus Erythematosus?
    I have been diagnosed with SLE: Systemic Lupus Erythematosus, but for the moment it remains cutaneous. What are the chances for the disease to spread and attack other tissues? And if that does happen, is there any medication that can prevent the disease from permanently damaging the organs?

    I’m so scared, please help.
    Once you have this disease, do you have it for life?

    1. Linda R

      In some patients with cutaneous lupus, it does also turn into systemic lupus. Most cases of systemic lupus are mild to moderate and are controlled by medication and lifestyle changes. The majority of people with systemic lupus will live a relatively normal life span if they follow their treatment regimen (90%+). You said you have been diagnosed with systemic lupus. That means it is more than cutaneous. Many patients have both.

      The medications which control lupus are immunosuppressive drugs. Prednisone is the first line of defense in calming a flare, or period of disease activity. But prednisone can cause some problems at high doses and if taken for long periods of time. Most of us take hydroxychloroquine (Plaquenil) twice a day for life. This is preventive. For many patients the hydroxychloroquine is enough. If you have organ issues, then additional immunosuppressive drugs will be prescribed depending on what organ is involved.

      Lifestyle choices that help are:
      1. Eat a nutritious, balanced diet that is high in fruits and vegetables (at least 5 servings a day) and low in animal fat. Most of the time, avoid highly processed foods or fast food.
      2. Get some physical exercise on a regular basis.
      3. Learn stress management. Yoga, Tai Chi, meditation are all good tools.
      4. Learn about lupus so you can better manage it.
      5. Develop healthy and open communication with your physicians.
      6. Follow your treatment regimen and don’t be afraid to ask questions.
      7. Talk to others with lupus. I am 56, have systemic lupus with organ involvement, and lead a very full and happy life. 🙂
      8. Stay out of the sun PERIOD!

      There is no cure for lupus. You will have it for life. That said, you can learn to manage the lupus, work with your doctors and have a good life. Sure, it will be a little different from those who do not have lupus. You are the one who creates your new life with lupus. It is possible!

  3. Cess

    ANA test results help me please.?
    Two years ago my Titered Anti-Nuclear ABS was 1:320 speckled pattern SS-A. Doc never said a word and since then I have a new doc who said it was nothing. EVERTYHING I read says this is high and given I have Raynaud’s on my toes and today complained to him of lower back pain, would this be an indicator of something? I am trying to get the ANA repeated now for a more up-to-date result.

    The interp on the lab slip says “Speckled pattern SS-A (Ro) pattern >/=1:160 this distinctive pattern is confirmatory for Anti-SS-A (Ro). Anti-SS-A (Ro) may be seen in Sjogren’s syndrome, SLE and subacute cutaneous lupus.

    What does all this mean? Am I right in thinking that this could indicate an autoimmune disease?

    1. emtd65

      Yes you are. I had a doctor who tried telling me I was fine although the lab results said differently. In the mean time I was getting sicker. I had finally had it and requested all my records and went to another doctor. I did a lot of research on my own and documented my medical history going back to my childhood. So I went armed to my new doctor who at that point had no choice but to take me seriously. Turned out I was diagnosed with Lupus – SLE. ANA results can be elevated in people who have no symptoms at all and then there are those whose ANA are normal but have loads of symptoms. consider seeing a Rheumotologist and neurologist.

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