For centuries man has been trying to discover the key to reverse the effects of aging and to stay forever young. Myths have been told of a “fountain of youth” that gives immortality as long as a person bathes in it. Even the recent Disney movie Rapunzel eludes to the struggle against aging and the desire to maintain a state of permanent youth and vitality. What if I told you that scientists have recently made a major discovery that may hold the key to aging, cancer and a drastic increase in life expectancy?

Geneticist Richard Cathon and colleagues at the University of Utah have had major breakthroughs in their study of telomere's and the impact they have on aging. A telomere can be likened to a fuse on a bomb that is lit at the beginning of life and continues to burn until it reaches the bomb at the end of one's lifespan. Inside the nucleus of a cell all of our genetic material is located on double stranded molecules of DNA called chromosomes. Chromosomes are repeating patterns of four different nucleopeptides containing specific chemical codes that make each of us individually unique. Telomeres are the tips of these chromosomes that serve as a protector of the genetic material. This is similar to the plastic tip of a shoelace. As long as that tip is intact the shoelace will stay woven together. If the tip breaks off the shoe lace will fray and shred until it is no longer useable. As long as a telomere stays intact on a chromosome it can multiply and divide and accurately pass on the genetic material.

As we age our telomeres slowly begin shortening. At the beginning of one's life telomeres is around 10,000 base pairs of repeating nucleopeptides. Throughout the aging process that number will continue to drop to 5000 at the end of one's life span. A simple blood test can be done that will tell you exactly how long your telomere's, which can accurately predict the number of years an individual has left in their lives.

Many factors can prematurely shorten telomeres. A study has been done showing that stress, poor diet, lack of exercise all significantly shorten one's telomeres, which is probably why people who have significant stress, or poor health tend to be more susceptible to cardiac disease, diabetes, cancer and premature death.

The good news is, scientists have discovered an enzyme that reverses the shortening of telomeres. Telomerase is an enzyme that exists in the human body to prevent the shortening of telomeres as the cells divide. Infants, for example, have significantly higher levels of telomerase, which protects their telomeres as they are undergoing rapid growth and cell division. Cawthon and other researchers have discovered methods to replicate telomerase in the body and have seen significant age reversal in laboratory studies on mice and even on human subjects! Their research predicts that by taking supplements to boost telomerase they can increase life expectancy by at least 10-30 years!

Can you imagine a world where the life expectancy is 107 instead of today's 77 years? Can you imagine living well, feeling good, and staying active well past your 90s? The fountain of youth may be closer at hand and more attainable than we ever could have imagined!

About the author:

Source: http://www.sooperarticles.com/health-fitness-articles/genetics-articles/rebuilding-telomeres-key-longer-life-930219.html


double strand dna test for lupus

27 thoughts on “Double Strand Dna Test For Lupus

  1. Buzzybea15

    Has anybody got Systemic Lupas Erythematosis?
    I want to know if any1 has lupas please nad what age they are? and wht age they got it from if anybody doesnt know about it thats ok

    1. searching

      Systemic lupus erythematosis is an autoimmune disorder. It is mostly common in females within the reproductive age group and more in females than the males.This disorder presents with a set of clinical manifestations. There will be presence of malar rash (usually over the cheek bone area), oral ulcres, photosensitivity, joint pains, convulsions, some blood disorders, renal disorders, chest pains. It is not necesssary that all the symptoms will be present in the patient only a few too can be present. The best way to figure out whether one has SLE is to go to the clinic and do the necessary serological tests.
      Presence of smith antigen and antibody to double stranded DNA confirms the disease.

    1. Menthoids

      The testing of the antinuclear antibody titer, or ANA titer for short, is the most reliable test. 95% of patients with lupus are positive for the ANA titer. However, lower titers of this test can also be found in elderly patients or some patients with other autoimmune disorders.

      There is a cross connection between six autoimmune diseases, probably because they all involve autoimmune antibodies.

      Each of these has its own symptom expression. With a flare-up of lupus the sedimentation rate (ESR or erythrocyte sedimentation rate) is elevated and remains so for quite some time, even when the flare-up is abating. As infections can also have an increased ESR, other tests are needed to distinguish between lupus and infection.

      One such test is the C-reactive protein, which usually stays normal in a lupus flare, but is elevated in infection. Other blood tests show a low white blood cell count (“leukopenia”) and anemia. The anemia can be nonspecific or hemolytic. Low platelet counts less than 100,000 per microliter is also common with lupus.

      The ANA titer (result) usually tends to increase with a lupus flare and then get lower again when the flare is over. A more specialized test, antibodies to double stranded DNA, can be found in less than 50% of lupus patients.

      The main early symptoms are listed below: However they can occur for many things that are NOT Lupus, so don’t get thingy about them..as you will see a bout of the flu shares these symptoms…

      Several symptoms are seen in the initial stages of lupus. These include:
      – Fatigue, weakness and lethargy
      – Joint pain or swelling (experienced by about half of patients)
      – Skin rashes (around one in five patients)
      – Fever

      The link below has simple advice on the different types of Lupus, etc.

      Best wishes.

    1. swbarnes2

      It reveals that you have some kind of autoimmune disease. People diagnosed with lupus (SLE) also show positive on the double stranded DNA test.

      What is actually tested for are antibodies that react to double-stranded DNA. I believe it’s because it’s indicative of your cells being broken open and killed by your immune system, and the presene of DNA (which is not normally supposed to be floating around in your blood) triggers the activation of t-cells which are specific to dsDNA, and so they release antibodies.

  2. MissLaLa

    Lupus??? MS??? What is going on with me?
    I have had a lot of tests run lately and have had two come back that the doc is concerned about. I have a low white blood cell count and have a low positive ANA of 1:40 speckled. I have absolutely no idea what all this means. I did have a smith antibody and double stranded dna test done, both came back negative. Again, no clue what this means!! My doc is sending me to a rheumatologist but I can’t get in until March. So I have to continue to live with pain, fatigue and absolute frustration where I feel like no one is listening to me! I have very painful muscle spasms and joint pain. Sometimes my fingers shake and get weak and when they get cold sometimes turn white and painfully numb. Ugh! I’ve heard MS and Lupus and just hoping someone out there can give me some kind of insight!! I’m sure I’ve left something out as I have been battling this for several months…if you need more information please don’t hesitate to ask!

  3. FutureRN

    For experienced physicians: what diagnostics tests would you order if you suspected a patient had lupus??
    I’m currently completing a case study for Systemic Lupus Erythematosus and it would really help if I knew the correct tests. Please help!

    1. Linda R

      There are no definitive tests for lupus. In order to arrive at a diagnosis of lupus, one must first eliminate other disorders that can cause similar symptoms. After that, a combination of lab tests, medical history, and symptoms matched against the American College of Rheumatology’s 11 criteria for lupus and finding a match for 4, some carrying more weight than others.

      Tests for ANA, anti-double stranded DNA, sed rate, C reactive protein, ro and la, CBC, CMP, and 24 hour urine with protein excretion and creatine clearance can all provide clues.

      Dr. Sam Lim and the CDC are involved in the National Lupus Patient Registry in an attempt to find a specific, definitive biomarker for lupus.

      The link below can take you to common diagnositc tests for lupus.

  4. Anonymous

    Medical advice needed?
    So, recently I have had blood work done. I am a 17 year old female. My mother has SLE (systemic lupus erythematosus) and has had it for 23 years. When I went for an exam of my wrist, the doctor ordered an ANA and sed rate blood test. When the results came in, I hate an ANA of 1:80, my sed rate was high around 180, lyme disease was negative, and so was rheumatoid arthritis, and some others but I can’t remember what they were. When I went to a referred rheumatologist, she said that about 5% of the population had a 1:80 ANA but when I told her my symptoms and my recent weight gain over the the past year, she said that she wouldn’t rule out SLE, but she’d check my thyroid as well. She said she would do a double stranded DNA, Smith’s test (?), the urinalysis and the thyroid. What do you think?

  5. Gabe

    Can your regular doctor test you for lupus?
    I went to a doctor around november last year for chest pains and other problems and he said he thinks i might have lupus. i was supposed to go back to get further testing done but couldnt afford it at the time. I still have the same problems and would like to get tested at a local doctors office, so would they be able to do that? what tests are done?

  6. mb28

    I received a Positive ANA test but the Anit-DNA, ab Double Strand test didn’t detect anything..?
    I was hospitalized for Jaundice and itching, the dr thought it was from Methyldopa Blood Pressure Meds. The dr that saw me was a Gastroenterology Specialist, he said I have lupus but i don’t have any symptoms other then my liver was inflammed. Do you think I have lupus or go for a 2nd opinion? Please help

    1. wantsshy

      The positive ANA could indicate lupus… but lupus is often misdiagnosed repeatedly…. Go get a second, even third opinion when dealing with something like Lupus or any auto immune disease.

  7. Anonymous

    Medical advice needed?
    So, recently I have had blood work done. I am a 17 year old female. My mother has SLE (systemic lupus erythematosus) and has had it for 23 years. When I went for an exam of my wrist, the doctor ordered an ANA and sed rate blood test. When the results came in, I had an ANA of 1:80, my sed rate was high around 180, lyme disease was negative, and so was rheumatoid arthritis, and some others but I can’t remember what they were. When I went to a referred rheumatologist, she said that about 5% of the population had a 1:80 ANA but when I told her my symptoms and my recent weight gain over the the past year, she said that she wouldn’t rule out SLE, but she’d check my thyroid as well. She said she would do a double stranded DNA, Smith’s test (?), the urinalysis and the thyroid. What do you think?

    1. oh my

      it looks like your doctor is doing everything that needs to be done. wait for the results and listen to what the doctor has to say. you might get a second opinon. but at this point i think your doc is doing a good job

  8. gobzgirl

    Are there any definitive tests for connective tissue disorders?

    And if so, would a Rheumatologist be the one to diagnose such a thing?

    1. someoneoutthereishere

      Yes, a rheumatologist is the specialist to see. I have a CTD (lupus) and have had lots of tests. Some of the more common ones are ANA (positive in most people with a CTD), and anti-dsDNA (double stranded DNA).

      The pattern of your ANA can also be tested, I think it’s an addon test that’s not done as much as the standard positive/negative. I believe that most people with CTD have a “speckled” pattern on the ANA – but could be mistaken.

      Since there are so many types of CTDs, there are lots of tests. Some of them are very specific, but some are really hard to pin down (like Lupus). It took my rheumatologist about 8 months before I got a “firm” diagnoses; and I’ve heard that’s not abnormal at all. The problem with CTDs is that many of them are similar and mimic the symptoms of others.

      The symptoms you’re having are also very important. If you have something like Reynaud’s (fingers turning white/numb), that helps narrow it down a bit. Every little thing helps – so make sure to keep track and write down anything that’s bothering you.

      If you haven’t already, I’d talk to your primary doctor. Then he/she can refer you to a rheumatologist if they think it is something likely.

      While I can’t say much about any of the other CTDs besides Lupus, I think most of them are treated more as a “management” type of ongoing treatment, rather than a cure. As I’m sure you’re already aware, it’s not like an infection that you can just take some antibiotics and get rid of. You may have to deal with the symptoms lifelong, but with the proper medication and doctor’s help, they can be much less obtrusive. I personally take Plaquenil and Imuran, which suppress the immune system, which helps keep it from attacking itself even more. Depending on your diagnoses, you may take something similar, or something completely different. Rheumatology is a fairly new medical field compared to most others, so it’s evolving pretty quick.

      Good luck with it all, hopefully you won’t have any major problems. If you do, just take it one day at a time.

  9. dumbbrunnett88

    What blood tests can be used to diagnose Lupus?
    I am almost positive that I have lupus, as I have almost every one of the symptoms. My doctor also thinks that i may have lupus, but every time i get a blood test, everything is negative. What tests can be used to diagnose lupus? Because i want to find out for sure if this is what I have
    I was already diagnosed with fibromylagia but my symptoms go beyond just that. I have also been tested numerous times for Lyme disease and other rheumatic diseases, all coming out negative.

    1. eabena

      Raised ESR. Reduced white cells, reduced lymphocytes, and/or reduced platelets. Serum antinuclear antibodies (ANA) is positive in almost all cases. Double-stranded DNA (dsDNA) is specific to lupus but is only present in 50% cases. Anti-Ro and anti-La can also be detected. 25% patients have rheumatoid factor. Reduced serum complement levels during active disease.

    1. missbunnyboo

      The only blood test that I have heard of relating to double-stranded DNA is an antibody test. In certain autoimmune diseases, most commonly lupus, the body’s immune system becomes activated against normal components of your body rather than what it should be attacking (foreign things). In lupus, the body produces antibodies against double-stranded DNA (genetic material). A positive lab test could indicate that the person has lupus. With that said, lupus is a very complicated disease to diagnose. They would never diagnose it based on a single positive lab test. An immunologist or rheumatologist could explain in detail exactly what is needed to diagnose lupus.

    1. Orinoco

      Yes – particularly if you have the clinical features (particular rash, joint aches and pains, anaemia, pericarditis, kidney problems … etc.)

      The various antibody tests are all testing for antibodies to this and that … smooth muscle, double stranded DNA, cell nucleus, microsomes, etc…

      You can have lupus if many of the antibodies are present, but one (in your case anti-dsDNA antibody) comes out negative.

      Anti-dsDNA antibody is highly specific, but only 70% sensitive.

      That means that if you HAVE it, there is a very good chance you have lupus.

      If you don’t have it, you might have something else, but it might still be lupus.

  10. I Wanna Know Damn It!!!

    Do I have Lupus, my test results are confusing?
    My ANA test came back positive but my DNA Antibody Double Stranded test came back negative! What could this mean? Another Autoimmune Disease?
    My ANA test came back positive but my DNA Antibody Double Stranded test came back negative! What could this mean? Another Autoimmune Disease? This just came up in a routine doctor visit blood test then I saw a Hematologist who sent me to a Rhuemetologist. I have no other symptoms except Raynaud’s syndrome (12 years).

    1. M. L

      You’re ANA test, as positive, only shows that you have an auto-immune disease. If you already have Raynaud’s Syndrome then this alone would cause a positive result in the ANA test. Ask you’re doctor to give you another ANA test with Reflex Titer. This will actually tell you what auto-immune disease(s) that you have. Good Luck!

Leave a Reply

Your email address will not be published. Required fields are marked *