Question: How Does Heparin Help Treat Recurrent Miscarriagesc

Heparin is an injectable blood thinner. Doctors sometimes prescribe heparin to women with antiphospholipid syndrome or other blood-clotting disorders that are linked to recurrent pregnancy loss.


Recurrent miscarriages occur due to a number of causes. Some causes are more well understood than others, and in many cases, there is no known cause for recurrent miscarriages. One of the few medical factors doctors agree upon in recurrent miscarriages is thrombophilia disorders, or medical conditions in which the blood has an increased tendency to clot. The thrombophilia disorder most clearly tied to miscarriages is antiphospholipid syndrome.

In thrombophilia disorders, researchers believe that tiny clots get stuck in the developing placenta, blocking flow of nutrients to the baby and eventually causing miscarriage (or increasing risk of other pregnancy complications, such as pre-eclampsia). It’s also been theorized that thrombophilia disorders might cause other problems with the placenta.

For women with diagnosed thrombophilia conditions and recurrent miscarriages, a common treatment is heparin — often alongside low-dose “baby” aspirin. Heparin injections thin the blood and decreases the tendency to form clots. Evidence suggests that heparin treatment during pregnancy reduces miscarriage rates for women with antiphospholipid syndrome and possibly benefits women with inherited thrombophilia disorders, such as Factor V Leiden mutations.

Using heparin during pregnancy is not without risk; the drug can have side effects in some people and may increase the risk of bone loss or tendency to hemorrhage. But for women with antiphospholipid syndrome, the benefits likely outweigh the risks.

Some experts had theorized that heparin might be beneficial for women with recurrent miscarriages and negative tests for antiphospholipid antibodies, postulating that unexplained recurrent miscarriages could be due to some unrecognized blood clotting disorder, but a 2010 study found that neither heparin nor low-dose aspirin improved birth rates for these women compared to placebo. Heparin treatment is usually recommended only in women with both a history of miscarriage and a confirmed diagnosis of antiphospholipid syndrome or an inherited thrombophilia disorder.

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4 thoughts on “Lupus Anticoagulant Miscarriage Symptoms

  1. msnoname7

    The difference between APS and Lupus?
    So if someone has the Lupus Anticoagulant antibody is that one of the ANA’s that is needed to be diagnosed with Lupus? I have been diagnosed with Antiphosolipid Antibody Syndrome because of the antibody, the multiple miscarriages, TIA’s and clotting etc. However, I also have many many symptoms of Lupus are the terms interchangable?

    1. Deb

      I would think so.
      I was told by a doctor that I had Lupus but upon checking into it further cuz I certainly was not going to let that one go, so I checked with another doctor, he said that my ANA showed it was positive for Lupus but my level was not indicitive of a level that I had to worry about, he said, most everyone will show a positive for that ANA factor/level to some degree, however it’s termed. But that doesn’t mean I actually have Lupus, apparently the first doctor that told me that, had no clue what level the ANA should show to diagnose someone like that, he scared me.

  2. cortlin.harrison

    is this a good research project please be honest?
    Cortlin Harrison Science 10-12
    Mrs. Cooney/ Mrs. Barends ELA 21-23
    May 19, 2009
    Antiphospholipid Syndrome

    Antiphospholipid Syndrome is a disorder in which the body recognizes certain normal components of blood and/or cell membranes as foreign substances and produces antibodies against them. This disorder is non-infectious which means that this disorder can’t be passed from person to person by contact. Pregnant women are more prone to get this disorder than anyone else, and African Americans, and Hispanics but like other disorders anyone can get Antiphospholipid Syndrome

    The symptoms and characteristics of this disorder are not hard to spot. Some symptoms of the disorder are veins or arteries of the arms or legs may cause pain, numbness, tingling in the feet. Arteries of the heart may cause chest pain or heart attack, the individual with this disorder may have heart murmur. In pregnant women with Antiphospholipid Syndrome, miscarriage can occur prior to 20 week of gestation, while pre-eclampsia is reported to occur after that time. Blood vessels of the skin – may cause painful bruises (purpura) or a condition called livedo reticularis. Blood vessels of the brain – if a clot cuts off blood supply to a part of the brain, this causes a stroke. An individual with APS may also experience migraine headaches or seizures.

    There is no cure and there is no way to avoid getting this disorder. There are many treatments for this disorder. But the most successful treatment is anticoagulant therapy. This is usually successful in preventing further blood clots. This disorder can severely damage the body in many different ways because good cells attack other good cells and that causes chaos through the body. And when a weak or strong pathogen enters the body it can be deadly.

    Some other information about Antiphospholipid Syndrome is, 1-5% of the world population is known to have this disorder, and 40-50% of patients with lupus also have APS. One third of strokes occurring in younger people (under the age of 50) are due to Antiphospholipid Syndrome. One third of patients with Antiphospholipid Syndrome are said to have lupus, and or Raynaud disease. APS is more common in young to middle-aged adults; however, it also manifests in children and elderly people. Disease onset has been reported in children as young as 8 months.

    This disorder is very rare and not very deadly but this disorder can still affect your way of life, the way you think, and can make you dizzy and other things. My mom has this disorder and sometimes it’s hard to get around and such, but you can still fight back by eating a healthy diet and seeing a special doctor called a Rheumatologist, this doctor specializes in these types of rare disorders.

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