An FDA panel has unanimously approved a new type of blood-thinning medication, Pradaxa (dabigatran etexilate) to help prevent stroke in people with atrial fibrillation. Atrial fibrillation (AF) is an irregular heartbeat in which the heart’s two small upper chambers (the atria) quiver instead of beating strongly. As a result, blood isn’t pumped completely out of them, and the trapped blood may pool and clot.

Atrial fibrillation is dangerous because of the risk that a clot may leave the heart and travel to the brain, resulting in a stroke. About 15% of strokes are a result of atrial fibrillation. AF can also lead to heart failure. The American Heart Association recommends aggressive treatment of this abnormal heart rhythm disorder, which affects about 2.2 million Americans – 3 to 5 percent of people over 65.

AF symptoms include dizziness or light-headedness, shortness of breath, fatigue, weakness, heart palpitations, a racing heart and chest pains, although some people have no obvious symptoms. The best way to confirm if you have AF is to have an electrocardiogram to measure your heart’s electrical activity. Atrial fibrillation can be caused by a heart attack, coronary artery disease, heart valve disease, high blood pressure or other medical problems. Heavy alcohol use, smoking, high consumption of caffeine, and use of illegal stimulants like cocaine and some prescription drugs (including decongestants and asthma medications) can also lead to atrial fibrillation.

Antiarrhythmics – prescription drugs to restore the heart’s natural rhythm – are the first line of defense against AF, along with lifestyle changes like quitting smoking, exercising, avoiding caffeine and alcohol and adopting a heart-healthy diet. Anticoagulant drugs, also known as blood thinner medications, are frequently prescribed to thin the blood and avoid the formation of clots. If AF symptoms fail to improve with prescription medications, electric shock to restore the heart’s regular beating pattern, radiofrequency ablation (cauterization of the problem area), surgery or insertion of an atrial pacemaker may be the next approach.

The newly approved Pradaxa is the first of a novel class of anticoagulant medication which inhibits an enzyme involved in blood clotting. In clinical trials, people with atrial fibrillation taking Pradaxa had fewer strokes than those taking the commonly prescribed anticoagulant medication warfarin. Warfarin is difficult to use as patients must be monitored with periodic blood tests, and the blood thinning medication interacts negatively with many other drugs and some foods. Germany’s Boehringer Ingelheim Pharmaceuticals Pradaxa is marketed in 75 mg and 110 mg capsules. Several American pharmaceutical companies are rushing to develop or get FDA approval for similar medications.


3 thoughts on “Lupus Anticoagulant Panel Test

  1. ukind

    problem of repetitive abortions?
    Dear Sir/Madam,
    We are suffering from three continous aborations,
    We had first mis-carriage in the month of July 2007 and this was 6-week pregnancy. After getting jerk in auto-ricksaw, We had to
    go for D&C.

    For Second pregnancy we tried from month of Jan 2008 and we both took medicine Blong and Lycobal finally she is
    able to concive in the month of may 2008 and tests done before pregnacy were
    1) TSH,
    2) Torch IGg, Torch IGm,
    3) Hb,
    4) Serum Prolactin,
    out of these Torch IgG was positive,
    and during pregnacy she were on Duphestron, ecospine, folinext and corion injection (weekly), and she was suffering from vaginal discharge (brown color
    liquid) started from early pregnancy, and there was heart beat measured (95/min). One day she had heavy bleeding we had to gone through D&C again
    in month of Aug 2008. And karyotyping of aborted was Normal. Again this was around 6 week pregnancy.

    For third pregancy, we tried from month of Jan 2009 and she is able to conceive at end of Jan 2009,
    Before pregancy, she was taking tablets folic acid and becasole-z. We did follwing tests before third pregancy
    1) Anti phospholipid Antiboby IgG and IgM,
    2) Cardiolipin Antibody panel
    3) DIlute Russell Viper Venon Line , Lupus Anticoagulant by dRVVT
    4) GTT
    5) Anti B2 Glycoprotein 1
    6) Lupus Anticoagulant
    7) Progolac C
    8) Hb (HB, PLV, ESR, TLC, DLC, Plt C)
    All tests were normal.
    and during third preganacy she were on Tab esscuit, Duphastron, HucoG 5000 mg injection(weekly)
    and during preganacy USG report says there is bicornuate/septate location preganacy and we had to gone thorugh D&C again in month
    of march 2009, We did our karyotyping and karyotyping was normal for both of us,

    After third mis-carriage, doctor advised us to do below tests along with laproscopy and histroscopy
    1) TB IGg, IgM,
    2) TB PCR (Normal),
    3) TB PCR (M. Blood)
    4) N.K Cell
    5) TNF alpha
    6) Secrun prolatin estimation ,
    7) Montex
    8) HSG (Normal)
    9) chest X-ray,
    10)whole abdomental USG,
    11) APTT,
    12) CBC,
    13) glucose fasting,
    14) partial thrombolastin ,
    15) VDRL serum,
    16) HBG AG screen,
    17) Urine culture
    out of above tests TNF alpha and TB IgG was positive and doctor advice AKT4, but she took only for two months
    as during laproscopy and histroscopy doctor says there is no infectiob like TB,
    laproscopy and histroscopy done in month of sept 2009.
    In laproscopy and histroscopy doctor said uterus was sub-septate and he removed the septum, and removed shringe of tubes also.

    Please advise, what could be root cause of problem of repetitive abortions,

    MAny Thanks,

    1. zannyvon

      I am truely sorry your having such a hard time with this. I do not have the answer you are looking for but a bit of advice you may want to post this under trying to concieve and change title of question to “problem of repetitive miscarriages” the folks in TTC may be better able to help you out and understand much more than most of us medical test wise and such. also in a place like this the word abortion tends to rile people up and some will not even look at a question assuming you mean that you are intentionally aborting.

      Prayers and baby dust your way 🙂

  2. ukind

    We are suffering from three continous mis-carriage?
    Dear Sir/Madam,
    We are suffering from three continous mis-carriage,
    We had first mis-carriage in the month of July 2007 and this was 6-week pregnancy. After getting jerk in auto-ricksaw, We had to
    go for D&C.

    For Second pregnancy we tried from month of Jan 2008 and we both took medicine Blong and Lycobal finally she is
    able to concive in the month of may 2008 and tests done before pregnacy were
    1) TSH,
    2) Torch IGg, Torch IGm,
    3) Hb,
    4) Serum Prolactin,
    out of these Torch IgG was positive,
    and during pregnacy she were on Duphestron, ecospine, folinext and corion injection (weekly), and she was suffering from vaginal discharge (brown color
    liquid) started from early pregnancy, and there was heart beat measured (95/min). One day she had heavy bleeding we had to gone through D&C again
    in month of Aug 2008. And karyotyping of aborted was Normal. Again this was around 6 week pregnancy.

    For third pregancy, we tried from month of Jan 2009 and she is able to conceive at end of Jan 2009,
    Before pregancy, she was taking tablets folic acid and becasole-z. We did follwing tests before third pregancy
    1) Anti phospholipid Antiboby IgG and IgM,
    2) Cardiolipin Antibody panel
    3) DIlute Russell Viper Venon Line , Lupus Anticoagulant by dRVVT
    4) GTT
    5) Anti B2 Glycoprotein 1
    6) Lupus Anticoagulant
    7) Progolac C
    8) Hb (HB, PLV, ESR, TLC, DLC, Plt C)
    All tests were normal.
    and during third preganacy she were on Tab esscuit, Duphastron, HucoG 5000 mg injection(weekly)
    and during preganacy USG report says there is bicornuate/septate location preganacy and we had to gone thorugh D&C again in month
    of march 2009, We did our karyotyping and karyotyping was normal for both of us,

    After third mis-carriage, doctor advised us to do below tests along with laproscopy and histroscopy
    1) TB IGg, IgM,
    2) TB PCR (Normal),
    3) TB PCR (M. Blood)
    4) N.K Cell
    5) TNF alpha
    6) Secrun prolatin estimation ,
    7) Montex
    8) HSG (Normal)
    9) chest X-ray,
    10)whole abdomental USG,
    11) APTT,
    12) CBC,
    13) glucose fasting,
    14) partial thrombolastin ,
    15) VDRL serum,
    16) HBG AG screen,
    17) Urine culture
    out of above tests TNF alpha and TB IgG was positive and doctor advice AKT4, but she took only for two months
    as during laproscopy and histroscopy doctor says there is no infectiob like TB,
    laproscopy and histroscopy done in month of sept 2009.
    In laproscopy and histroscopy doctor said uterus was sub-septate and he removed the septum, and removed shringe of tubes also.

    Please advise, what could be root cause of problem of repetitive abortions,

    MAny Thanks,

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