Cushing’s syndrome is a rare endocrine disorder caused by high levels of cortisol in the blood. Sometimes called “hypercortisolism. It is relatively rare and most commonly affects person aged 20 to 50. An estimated 10 to15 of every million people are affected each year. Cushing’s syndrome occurs when the body’s tissues are exposed to excessive levels of cortisol for long periods of time. Many people suffer the symptoms of Cushing’s syndrome because they take glucocorticoid hormones such as prednisone for asthma, rheumatoid arthritis, lupus and other inflammatory diseases, or for immunosuppression after transplantation. Cushing’s syndrome is also a relatively common condition in domestic dogs in which causes are the same as the syndrome in humans, and in horses, (where it is almost invariably caused by pituitary neoplasia) characterised by a long, tightly curled coat which does not shed and abnormal fat deposition. The syndrome in horses leads to weight loss, polyuria and polydipsia and may cause laminitis.

Cushing’s disease is the name given to a type of Cushing’s Syndrome caused by too much ACTH production in the pituitary. The most common cause of Cushing’s syndrome is the use of oral corticosteroid medication. Common symptoms of Cushing’s syndrome include upper body obesity, severe fatigue and muscle weakness, high blood pressure, backache, elevated blood sugar, easy bruising, and bluish-red stretch marks on the skin. Risk factors for Cushing syndrome are adrenal or pituitary tumors, long-term therapy with corticosteroids, and being female. Many people suffer the symptoms of Cushing’s syndrome because they take glucocorticoid hormones such as prednisone for asthma, rheumatoid arthritis, lupus or other inflammatory diseases. Cortisol performs vital tasks in the body. It helps maintain blood pressure and cardiovascular function, reduces the immune system’s inflammatory response, balances the effects of insulin in breaking down sugar for energy, and regulates the metabolism of proteins, carbohydrates, and fats.

Common findings on routine laboratory tests in people with Cushing’s Syndrome include a higher white blood count, a high blood sugar (often into the diabetic range), and a low serum potassium. One of cortisol’s most important jobs is to help the body respond to stress. Some rare tumours in other parts of the body sometimes make ACTH. For example, some types of lung cancer. The ‘ectopic’ ACTH then stimulates the adrenals to make too much cortisol. People suffering from depression, alcoholism, malnutrition and panic disorders also have increased cortisol levels. Treatments for Cushing’s syndrome are designed to lower the high level of cortisol in your body. Cushing’s syndrome is treated by restoring a normal balance of hormones. Cushing syndrome caused by an adrenal tumor is usually treated by surgical removal of the tumor.Hormone supplements are usually given before surgery and must be taken for weeks and sometimes months after surgery, until the second gland recovers normal function. Medications to control excessive production of cortisol include ketoconazole (Nizoral), mitotane (Lysodren) and metyrapone (Metopirone). Medical therapy is also sometimes used before surgery for people who are very sick.

Treatment for Cushing’s disease Tips

1. Cushing’s syndrome is treated by restoring a normal balance of hormones.

2. Cushing syndrome is usually treated by surgical removal of the tumor.

3. Hormone supplements are usually given before surgery and must be taken for weeks and sometimes months after surgery, until the second gland recovers normal function.

4. Medications to control excessive production of cortisol include ketoconazole (Nizoral), mitotane (Lysodren) and metyrapone (Metopirone).

5. Radiation therapy-Radiation can be given in small doses over a six-week period, or by a technique called stereotactic radiosurgery or gamma-knife radiation.

6. Chemotherapy – radiation treatments of the pituitary gland (to weaken it and lower its output of ACTH) – or removal of any benign growths of the pituitary gland.

7. Adrenal adenomas are always treated by surgically removing the tumor with either an abdominal or side (flank) incision.


18 thoughts on “Lupus Causes Symptoms Treatment

  1. jaz mie

    what is SLE(Systemic Lupus Erythematosus)?
    please explain to me SLE (Systemic Lupus Erythematosus) more, so i can fully understand the illness.
    i want to know about the possibility of death on teenagers who suffer SLE.
    are there teenagers who’re aware of their illness and can already predict when they’ll pass away?
    are there cases like this?
    who are the persons who’re usually having SLE?
    what are the causes?symptoms?treatments?
    do they have medications?

    thanks!

    1. mlk_maid

      Lupus attacks your organs. Usually a butterfly rash across the nose and cheeks is a common first sign. There are treatments for arthritic that help with inflammation, also chemotherapy in small doses (pill form) help slow it down. I don’t believe there is a specific test to diagnose it. It is usually diagnosed on symptoms. Prognosis depends on the severity of it. A lot of people live a normal life with it.

    1. Anama

      It is an autoimmune disease, and to explain it here would be silly when there are literally thousands of sites dedicated to lupus. There is a search engine on yahoo! ,please try using that.
      Suggestions:
      Lupus cdc
      Lupus foundations

  2. Dance-a-Holic

    I need help editing my research paper. I’m really bad at papers…..please help!?
    Well, its on lupus. I have the intro and two body paragraphs, and I still need to do the conclusion. So, I was wondering what I should change on my paper, and what I need to add..? I also have to do a powerpoint based on the paper, that should last a minimum of 5 minutes up to 15.

    The reason why I chose this topic was because my dad has lupus, and I wanted to know more about the topic. He was diagnosed with lupus when he was about fourteen years old. He still receives treatment for it by going in for blood tests and taking medication He has the most common form of lupus, Systemic Lupus Erythematosus (SLE), in which causes the antibodies to react against his own normal tissue. He has arthritis and joint problems, but nothings wrong with his internal organs. To support my dad and other lupus survivors, my family and I all go to the lupus walk in honor of remembering the people who had lupus that died. The things the audience can expect to read in this paper are the different types of lupus, the symptoms, the treatment and cures.
    Lupus is the result of an unbalanced immune system that can be destructive to any organ in the body. It can be categorized into three groups: discoid lupus Erythematosus, systemic lupus Erythematosus, and drug-induced systemic lupus Erythematosus. DLE is always limited to the skin and is identified by a rash that may appear on the face, neck, and scalp. It can evolve into the systemic form, which can affect any organ or system of the body. Systemic lupus Erythematosus is more severe than discoid lupus and can affect almost any organ or organ system of the body. No two people with SLE will have identical symptoms. Drug-induced systemic Lupus Erythematosus occurs after the use of certain prescribed drugs. It is more common in men, because the drugs are given to them more often.
    Lupus is hard to diagnose because it has a wide range of symptoms involving various parts of the body; and symptoms differ from each person. Most people develop painful joints and a rash, but lupus may also cause fatigue, depressions, and kidney problems. The treatment of lupus varies from person to person because each person has different symptoms. Most people with SLE require a regular blood test to check for lupus flares. Medication is the primary medical treatment for lupus. Presently, there are no other methods available to treat lupus because there is nothing else that can have the necessary impact on the immune system. Currently, there is no cure for lupus, but with early diagnosis and proper medical treatment it can significantly help control the disease.

    thanks. it would be much appreciated!!!!

  3. wingsovgrace

    Have you been diagnosed with drug induced Lupus ?
    !0 years ago began having problem with elevated blood pressure. Was treated with the usually prescribed meds. Within the past ten years I have had a variety of unusual and often preplexing symptoms that the doctors couldn’t find good answers for. Lots of guesses and lots of unsuccessful treatments and increased frustration and misery until recently. The diagnosis is drug induced Lupus and it is believed to be caused by my blood pressure meds. Bingo. The symptoms have developed over the same period I’ve been on the meds. My question is: Any known effective alternatives for Blood Pressure Control? Anyone else with Lupus have bizarre skin and hair folllicle issues? Any one know a reputable doctor in Kansas City Missouri to advise on alternative treatments? Any one know of a web site to purchase alternative B/P treatments that you or someone you know have had personal experience with? Are there suggestions for a great support website for Lupus?

    1. Healing Oneself

      Hi WIngsOfGrace

      Here are some ideas to heal the issue. Also learning about detoxifying the blood by doing colon and liver cleanses will change your health forever.

      Cause
      Food allergies (there is a 100 percent correlation between lupus and food allergies), rheumatoid arthritis, other connective tissue diseases, parasites, candidiasis, bowel problems, and digestive enzyme deficiencies can create symptoms that mimic or exacerbate SLE. Migraines, epilepsy, and psychoses must also be ruled out before a proper course of treatment can be decided upon.

      Both forms of lupus primarily strike young women (90% of cases) and young children.

      The drugs hydralazine, procainamide, and beta blockers can cause false-positive readings of SLE, and can also produce a lupus-like condition that disappears when the drugs are no longer taken. Birth control pills and environmental stresses can also exacerbate lupus symptoms.

      ——————————————————————————–

      Natural Cures

      Diet: Eat an organic, whole foods diet. Also avoid overeating and limit your intake of dairy, beef products, and polyunsaturated oils. Also screen for food allergies and avoid all foods to which you are allergic or sensitive. Increase your intake of vegetables, especially green, yellow, and orange, and consume non-farm-raised fish several times a week.

      Herbs: Supplementation with Swedish bitters with each meal can increase hydrochloric acid production. Also drink an infusion of nettle twice a day. Other useful herbs include echinacea, goldenseal, licorice, pau d`arco, and red clover

      Hydrotherapy: Hydrotherapy is the application of water, ice, steam and hot and cold temperatures to maintain and restore health. Treatments include full body immersion, steam baths, saunas, sitz baths, colonic irrigation and the application of hot and/or cold compresses. Hydrotherapy is effective for treating a wide range of conditions and can easily be used in the home as part of a self-care program. Many Naturopathic Physicians, Physical Therapists and Day Spas use Hydrotherapy as part of treatment.

      Hyperthermia: Hyperthermia involves artificially creating fever in the body for the purpose of boosting immune function. Hyperthermia can be a highly effective method of eliminating toxins and heavy metals, as well as infectious bacteria and viruses that cannot survive in elevated body temperatures.

      *Purified water is essential for any hydrotherapy or hyperthermia treatment. Remedies for Treating Chlorinated Bath Water offers clear instructions and recommendations.

      Juice Therapy: Drink the juice of carrot, celery, flaxseed oil, black currant oil, and garlic.

      Nutritional Supplementation: Hydrochloric acid (HCL) deficiency is common in people with lupus, therefore HCL supplements with each meal is advised. Other useful nutrients include vitamin A with beta carotene, vitamin C and bioflavonoids, vitamin B complex, vitamin B5, vitamin B6, vitamin B12, calcium, magnesium, selenium, zinc, essential fatty acids, proteolytic enzymes taken away from meals, digestive enzymes taken with meals, and the amino acids L-cysteine, L-methionine, and L-cystine.

      Topical Treatment: PABA cream applied topically can help ease symptoms.

      Best of health to you

  4. sante

    I am so afraid to take plaquenil for lupus treatment! any natural cure?
    Does anyone has an experience with plaquenil? or some one knows a natural way to cure lupus? I am currently taking oil fish, cellfood and recovery( for joint pain) and multi-vitamins.

    I am 30 yrs and was diagnose 8 months ago, no internal organs involves and the only symptoms are fatigue and joints pain.

    Please help if you have experience plaquenil as treatment or someone else. I am afraid of side effects ( affects lung, kidney, bones , eye etc.) it help now but causes you trouble later on.

    I am going to see my rhumatologist tomorrow but I haven’t decided yet if i am going to start the treatment.

    thanks

    1. Science Geek

      You do realize what lupus is right?

      Listen, I know you’re scared. Anybody would be with that diagnosis. But the drugs are safe. The side-effects are minimal. Not taking the drugs and pretending that there is a natural cure is dangerous. You need to understand that the drug was prescribed because it was proven effective in the treatment of lupus. There are side-effects with any drug, even natural ones. What you need to do is weigh the potential benefits of taking the drug versus the potential consequences of side effects and of not taking the drug. Lupus is a highly treatable disease but there is no cure for it. The treatments are proven to be effective and safe as long as you follow the doctors orders.

  5. sante

    I am so afraid to take plaquenil for lupus treatment! any natural cure?
    Does anyone has an experience with plaquenil? or some one knows a natural way to cure lupus? I am currently taking oil fish, cellfood and recovery( for joint pain) and multi-vitamins.

    I am 30 yrs and was diagnose 8 months ago, no internal organs involves and the only symptoms are fatigue and joints pain.

    Please help if you have experience plaquenil as treatment or someone else. I am afraid of side effects ( affects lung, kidney, bones , eye etc.) it help now but causes you trouble later on.

    I am going to see my rhumatologist tomorrow but I haven’t decided yet if i am going to start the treatment.

    thanks

  6. angelinaismywifey

    My LYMPH NODES are extremely palpable (for years) i have lost TOO MUCH WEIGHT, what is wrong?
    Hello….if anyone would like to try to DIAGNOSE ME, I’d be SO GRATEFUL AT THIS POINT!
    ….. i’m 30 year old female, with a 10 year old son and had a thoracic fore gut tumor(benign) removed from my chest @ 15, a good portion of which was attached to my lungs, aorta,esophagus, Trachea.
    To Date- no known complications or regrowth.
    109 lbs
    5’3″
    hypothyroid, on synthroid
    Had IUD recently placed in cervix
    amphetamine salts,celexa, lorazapam for depression/fatigue and ADD
    MY SYMPTOMS:
    CURRANTLY AND THIS PAST YEAR: Generalized Swollen lymph glands(some firm and hard in groin area. Also where my hairline is in the back of my neck behind my ear i guess, and a few large ones up the side of my neck aligned with my shoulder), Re currant low Grade Fever(no higher than 101 w/out infection),Itchy Skin, Memory Loss,Hair loss, Acne,Bowel Changes,On and Off fatigue, mucus in my stool(for one year at least.More mucus than actual stool on average! SORRY TO BE SO GRAPHIC! Lower Back Pain, DULL ACHING PAIN on the inside of my knees,stiff neck,ankle pain after being on my feet for more than an hour.Also extremely dry; mouth,skin,hair,eyes,&nostrils, dizziness upon standing, sweats,wounds heal slowly, weird painless swelling above my butt where my dimples are(no dr has been able to guess why/what this swelling might be),diarrhea and constipation, tenderness above my belly button, hyper pigmentation on abdomen, arms and feet, anxiety, blood pressure has steadily increased throughout all of my many dr’s visits this past yr.
    ADDED RECENT SYMPTOMS:Kidney pain, visible blood in urine: for 2 months now! it was bright red and then less visible for awhile and now dark brown like tea and extremely strong smelling, hardening and bloating of abdomen, extreme fatigue, productive cough, chest pain, neck pain,easily exhausted, unexplainable bruises, muscle spasms and bulging type pain JUST under my rib on both sides separately, weird stabbing pain on my left groin area near my larger lymph glands that makes my tendon look swollen, thrush, protein in urine, HI albumin in urine, repetitive rbc in urine, BUT NO INFECTION!! (multiple negative cultures), kidney stone shows on CT in an area that is expected to be asymptomatic and may not even pass. BUT I DO HAVE difficulty urinating and cramping JUST PRESCRIBED CIPRO FOR A SECOND TREATMENT. (not sure exactly why since culture is consistantly negative)

    Many tests HAVE BEEN DONE: …..All Basics(CB C’s, liver, etc panels) + Lyme Disease,Hep(B,C etc), ANA,Sed Rate,R.F.,AIDS, Celiac Disease,Fecal Bacterial+Viral cultures,Lupus,Syphilis, Gonorrhea, Chlamydiae,Anemia, scleroderma, h. pylori, bladder cancer,
    P.C.P. says: hematologist &will do allergy & routine testing upon insurance ok
    E.N.T(ear,Nose&throat) says: inflammation or irritation down deep in my throat(but i smoke so…)
    GASTROENTROLOGIST says: gastritis, hemorrhoids,IBS, lymphoid aggragates in non lymph areas
    UROLOGIST says: extreme gross & microscopic unexplained hematuria, referral to hematologist(concerned about enlarged lymph’s in groin and unexplained hematuria———says kidney stone most likely not causing this amount of rbc,did FISH URINE TEST…NO CALL SO I’M GUESSING ALL CLEAR ON RESULTS)
    HEMATOLOGIST says: i’m thin so nodes are more palpable s we should wait. does not believe biopsy is neccessary at this point
    RHUEHEMATOLOGIST says: no signs autoimmune, non arthritic/ lupus like disease
    GYNOGYNECOLOGIST says: no infection, no discharge see urologist…
    DERMOTOLOGIST says: see rhuemotologist! lol, biopsied pigmented marks(inconclusive-possibe allergic reaction)

    i am waiting on results of a chest CT from HEMATOLOGIST because he heard alot in my lungs and another aids test(that’ll be 4 tests in the last yr(all negative)

    I’M SURE THERE IS MORE INFO I”M NOT OFFERRING
    but i can’t remember everything! lol any EDUCATED ADVICE would be appreciated
    THANK YOU!!!! i feel so helpless when i am sooo tired or weak….. i just want a solution!
    PLEASE HELP!

    1. PoisonTrees

      See what the CT results are. If you get no answers there, I would go to a different hematologist and insist on a biopsy. If you can’t get answers switch to a hospital that specializes in diagnostics.

  7. Kenny

    What causes a person to be sensitive to barometric joint pain?
    I am a 25 year old female and have had varying degrees of joint pain that coincides with barometric pressure changes—either from humidity and summer storms or when it gets extremely cold. I am wondering if this a normal reaction in a healthy young adult or if I could be showing symptoms of arthritis. I have always had joint pain, though when I have seen the doctor, it was always dismissed as growing pains. I feel it most in my knees and hips, but also in my tail bone. The pain varies from barely noticeable to a dull, throbbing, aching pain that is so uncomfortable I often cannot sleep. Again, no doctor has ever taken this seriously.

    I have a medical history of having several related autoimmune disorders though through some experimental medical treatments I have gone through, and they most likely will not come up again.

    I was on a heavy dosage of steroids for two years (100mg of prednisone) during my other treatment, and I noticed that the symptoms have increased since then. I have heard that long-term steroid use can affect bone and joint health, but not sure if that is true. I also had an ANA test while I was being treated for my other disorders that was slightly positive, but at the time, my condition was so critical that I did not ask if a weak ANA test could mean that I possibly have lupus or RA.

    I know that the internet isn’t a way to get a medical diagnosis, but I am interested in hearing from people that who have barometric joint pain, are in the medical field, have joint pain from steroid use, or have RA or lupus. Also, any advice on alleviating the discomfort??

  8. cortlin.harrison

    is this a good research project please be honest?
    Cortlin Harrison Science 10-12
    Mrs. Cooney/ Mrs. Barends ELA 21-23
    May 19, 2009
    Antiphospholipid Syndrome

    Antiphospholipid Syndrome is a disorder in which the body recognizes certain normal components of blood and/or cell membranes as foreign substances and produces antibodies against them. This disorder is non-infectious which means that this disorder can’t be passed from person to person by contact. Pregnant women are more prone to get this disorder than anyone else, and African Americans, and Hispanics but like other disorders anyone can get Antiphospholipid Syndrome

    The symptoms and characteristics of this disorder are not hard to spot. Some symptoms of the disorder are veins or arteries of the arms or legs may cause pain, numbness, tingling in the feet. Arteries of the heart may cause chest pain or heart attack, the individual with this disorder may have heart murmur. In pregnant women with Antiphospholipid Syndrome, miscarriage can occur prior to 20 week of gestation, while pre-eclampsia is reported to occur after that time. Blood vessels of the skin – may cause painful bruises (purpura) or a condition called livedo reticularis. Blood vessels of the brain – if a clot cuts off blood supply to a part of the brain, this causes a stroke. An individual with APS may also experience migraine headaches or seizures.

    There is no cure and there is no way to avoid getting this disorder. There are many treatments for this disorder. But the most successful treatment is anticoagulant therapy. This is usually successful in preventing further blood clots. This disorder can severely damage the body in many different ways because good cells attack other good cells and that causes chaos through the body. And when a weak or strong pathogen enters the body it can be deadly.

    Some other information about Antiphospholipid Syndrome is, 1-5% of the world population is known to have this disorder, and 40-50% of patients with lupus also have APS. One third of strokes occurring in younger people (under the age of 50) are due to Antiphospholipid Syndrome. One third of patients with Antiphospholipid Syndrome are said to have lupus, and or Raynaud disease. APS is more common in young to middle-aged adults; however, it also manifests in children and elderly people. Disease onset has been reported in children as young as 8 months.

    This disorder is very rare and not very deadly but this disorder can still affect your way of life, the way you think, and can make you dizzy and other things. My mom has this disorder and sometimes it’s hard to get around and such, but you can still fight back by eating a healthy diet and seeing a special doctor called a Rheumatologist, this doctor specializes in these types of rare disorders.

  9. sante

    Was I misdiagnose? lupus or weak immune system?
    8 months ago while I was pregnant, I was diagnose with lupus. But the only symptoms that I am experiencing is joints pain and fatique some times. My doctor said that all of my organs are fine, I do not have a butterfly face neither skin problem. I wonder if the diagnosis was wrong.

    Does a weak immune system can cause thoses symptoms? I refuse to go on hormones treatments and trying to work on strenghtening my immune system first and hopefully reverse the condition.

    your experience and advise are welcome

    1. reifguy

      lupus is many stages ,and there is discoid and systemic lupus ,the immune system isnt weak in lupus its reacting in a way damaging the body and causing problems and inflammations ,if your diagnosis wasnt correct or u doubt it ,get a second opinion from a rheumatologist ,diagnosing lupus isnt easy in early stages and once diagnosed many go through remissions and relapse ,

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