Toll-like receptor 9 (TLR9) often known as CD289 (cluster of differentiation 289), is a member of the Toll-like receptor family that recognizes pathogen-associated molecular pattern. TLR9 was first cloned and identified as a receptor for unmethylated CpG-DNA as well as for bacterial DNA. It is essential not only for pro-inflammatory cytokine production and other inflammatory responses, but it also plays a role in the induction of T helper 1 (Th1) acquired immune response and in the proliferation of B cells. Like all other members of the TLR family, TLR9 is composed of an extracellular domain containing multiple leucine-rich repeats (LRRs), a transmembrane region, and a cytoplasmic tail containing the conserved TIR domain. The TLR9 sequence encodes a 1032 aa protein containing 27 N-terminal LRRs with a calculated molecular weight of 116 kDa . The gene for TLR9 has been mapped to human chromosome 3p21.3. TLR9 is most closely related to TLR7 and TLR8 with 36% and 35% overall amino acid sequence identity, respectively and thus along with TLR7 and TLR8 constitutes a new sub-family of the TLRs.

9 thoughts on “Lupus Erythematosis

  1. spider1138

    Does anyone else have trouble convincing their doctor that discoid lupus is a delibitating illness?
    I was diagnosed with DL fifteen years ago and at first it was bearable though embarrassing. Now as I reach 50.. I find more significant symptoms developing, only to be ho-hahed by the doctor who says it’s just..”getting older”.

    1. gangadharan nair

      Approximately 90% of individuals with discoid lupus have only skin involvement as compared to more generalized involvement in systemic lupus erythematosis (SLE). Discoid lupus occasionally (1–5%) develops into SLE.

  2. ms_wolf

    How can I prove my medication is responsible for my condition? (lupus)?
    The medication I was taking was making me very ill, forgetful, I lost 3 stones and have an allergy to almost every thing. wheat, gluetin, citrus, loads more… As soon as I weened myself of this (because I realised what was happening) I got better, I ended up with ulceration, and all sorts. I have tissue damage around the eyes and ends of my fingers and thumbs. The go black and sometimes the palm of my hands.

    1. LittleOwl

      If you have symptoms while taking a drug, and those symptoms go away upon discontinuation of taking that drug, chances are, you are sensitive to that drug. Not as bad as a severe immediate allergic reaction, but a sensitivity.

      But from what you are describing, it doesn’t sound like you are experiencing drug induced lupus erythematosis – DIL. DIL can be triggered by the chronic use of certain drugs, and there are 38 known medications that can cause DIL, but the 3 main ones are: hydralazine, procainamide, and isoniazid. The symptoms of DIL include: fever, high blood pressure, skin lesions, and arthritis.

      I would tell your doctor about what’s happening, and see if you can’t be put on another drug. I have a whole list of drugs that I don’t take because of serious sensitivities. Not allergic, but as having a history of having reactions bad enough to not prescribe them anymore. Doxycycline is one of them, for example. I’m not allergic, but I can’t stand up straight when I’m on it.

      Good luck, and well wishes for your heath!

    1. Jimmy Bennett

      TO name a few

      Allergies Headaches
      Altitude Sickness Herpes Simplex
      Alzheimer’s Herpes Zoster
      Anemia HIV Infection
      Arrhythmia Influenza
      Asthma Insect Bites
      Bacterial Infections Liver Cirrhosis
      Bronchitis Lupus Erythematosis
      Cancer Multiple Sclerosis
      Candida Parasitic Infections
      Cardiovascular Disease Parkinsonism
      Cerebral Vascular Disease Periodontal Disease
      Chronic Pain Prostatitis
      Diabetes Type 11 Rheumatoid Arthritis
      Diabetic Gangrene Shingles
      Diabetic Retinopahty Sinusitis
      Digestion Problems Sore Throat
      Epstein-Barr Infection Ulcers
      Emphysema Viral Infections
      Food Allergies Warts
      Fungal Infections Yeast Infections
      Gingivitis
      Cancer- every type you can think of

      All can be cured with Food grade 35% H202 in the right dosage over a period of 1 week to 1 year following a loading phase and a sustained phase

      Day # -Number of Drops/ Times Per Day
      1 – 3 / 3
      2 – 4 / 3
      3 – 5 / 3
      4 – 6 / 3
      5 – 7 / 3
      6 – 8 / 3
      7 – 9 / 3
      8 – 10 / 3
      9 – 12 / 3
      10 – 14 / 3
      11 – 16 / 3
      12 – 18 / 3
      13 – 20 / 3
      14 – 22 / 3
      15 – 24 / 3
      16 – 25 / 3

      Maintenance Dosage
      In most situations after the above 21 day program, the amount of H202 can be tapered off gradually as follows:
      25 drops once every other day for 1 week
      25 drops once every third day for 2 weeks
      25 drops once every fourth day for 3 weeks

  3. <>

    Information on Lupus?
    What are some of the symptoms of systematic lupus erythematosis? Can I prevent flares by staying out of direct sunlight? UV light? information much appreciated

    1. Art

      Target drugs are immune bodies targeted specifically for the abnormal proteins found in cancer cells (the “target”). They are so highly specific they can destroy tumor cells while sparing normal cells.
      They can also be targeted to destroy immune complexes in such diseases as lupus erythematosis and rheumatoid arthritis.

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