Toll-like receptor 9 (TLR9) often known as CD289 (cluster of differentiation 289), is a member of the Toll-like receptor family that recognizes pathogen-associated molecular pattern. TLR9 was first cloned and identified as a receptor for unmethylated CpG-DNA as well as for bacterial DNA. It is essential not only for pro-inflammatory cytokine production and other inflammatory responses, but it also plays a role in the induction of T helper 1 (Th1) acquired immune response and in the proliferation of B cells. Like all other members of the TLR family, TLR9 is composed of an extracellular domain containing multiple leucine-rich repeats (LRRs), a transmembrane region, and a cytoplasmic tail containing the conserved TIR domain. The TLR9 sequence encodes a 1032 aa protein containing 27 N-terminal LRRs with a calculated molecular weight of 116 kDa . The gene for TLR9 has been mapped to human chromosome 3p21.3. TLR9 is most closely related to TLR7 and TLR8 with 36% and 35% overall amino acid sequence identity, respectively and thus along with TLR7 and TLR8 constitutes a new sub-family of the TLRs.

13 thoughts on “Lupus Sle Treatment

  1. sekhmet179

    What are the four stages of treatment for lupus?
    I remember reading somewhere that there were four stages of treatment for systemic lupus erythematosus I think it was like
    I-corticosteroids
    II-?
    III-?
    IV-Immunosuppressors, chemotherapy, etc

    I was wondering if there was anything like this on the internet or whether I am confusing it with the kidney affected stages? (I doubt it but you never know…)

    Thanks in advance for any info, and please be sure to set up a link to where you got your info

    1. Cheryl M

      What is the treatment for systemic lupus?

      There is no permanent cure for SLE. The goal of treatment is to relieve symptoms and protect organs by decreasing inflammation and/or the level of autoimmune activity in the body. Many patients with mild symptoms may need no treatment or only intermittent courses of antiinflammatory medications. Those with more serious illness involving damage to internal organ(s) may require high doses of corticosteroids in combination with other medications that suppress the body’s immune system.

      Patients with SLE need more rest during periods of active disease. Researchers have reported that poor sleep quality was a significant factor in developing fatigue in patients with SLE. These reports emphasize the importance for patients and physicians to address sleep quality and the effect of underlying depression, lack of exercise, and self-care coping strategies on overall health. During these periods, carefully prescribed exercise is still important to maintain muscle tone and range of motion in the joints.

      Nonsteroidal antiinflammatory drugs (NSAIDs) are helpful in reducing inflammation and pain in muscles, joints, and other tissues. Examples of NSAIDs include aspirin, ibuprofen (Motrin), naproxen (Naprosyn), and sulindac (Clinoril). Since the individual response to NSAIDs varies among patients, it is common for a doctor to try different NSAIDs to find the most effective one with the fewest side effects. The most common side effects are stomach upset, abdominal pain, ulcers, and even ulcer bleeding. NSAIDs are usually taken with food to reduce side effects. Sometimes, medications that prevent ulcers while taking NSAIDs, such as misoprostol (Cytotec), are given simultaneously.

      Corticosteroids are more potent than NSAIDs in reducing inflammation and restoring function when the disease is active. Corticosteroids are particularly helpful when internal organs are involved. Corticosteroids can be given by mouth, injected directly into the joints and other tissues, or administered intravenously. Unfortunately, corticosteroids have serious side effects when given in high doses over prolonged periods, and the doctor will try to monitor the activity of the disease in order to use the lowest doses that are safe. Side effects of corticosteroids include weight gain, thinning of the bones and skin, infection, diabetes, facial puffiness, cataracts, and death (necrosis) of large joints.

      Hydroxychloroquine (Plaquenil) is an antimalarial medication found to be particularly effective for SLE patients with fatigue, skin, and joint disease. Side effects include diarrhea, upset stomach, and eye pigment changes. Eye pigment changes are rare, but require monitoring by an ophthalmologist (eye specialist) during treatment with Plaquenil. Researchers have found that Plaquenil significantly decreased the frequency of abnormal blood clots in patients with systemic SLE. Moreover, the effect seemed independent of immune suppression, implying that Plaquenil can directly act to prevent the blood clots. This fascinating work highlights an important reason for patients and doctors to consider Plaquenil, especially for those SLE patients who are at some risk for blood clots in veins and arteries, such as those with phospholipid antibodies (cardiolipin antibodies, lupus anticoagulant, and false positive VDRL). This means not only that Plaquenil reduces the chance for reflares of SLE, but it can also be beneficial in ‘thinning’ the blood to prevent abnormal excessive blood clotting.

      For resistant skin disease, other antimalarial drugs, such as chloroquine (Aralen) or quinacrine, are considered, and can be used in combination with hydroxychloroquine. Alternative medications for skin disease include dapsone and retinoic acid (Retin-A). Retin-A is often effective for an uncommon wart-like form of lupus skin disease. For more severe skin disease, immunosuppressive medications are considered as below.

      Medications that suppress immunity (immunosuppressive medications) are also called cytotoxic drugs. Immunosuppressive medications are used for treating patients with more severe manifestations of SLE with damage to internal organ(s). Examples of immunosuppressive medications include methotrexate (Rheumatrex, Trexall), azathioprine (Imuran), cyclophosphamide (Cytoxan), chlorambucil (Leukeran), and cyclosporine (Sandimmune). All immunosuppressive medications can seriously depress blood cell counts and increase risks of infection and bleeding. Other side effects are peculiar for each drug. For examples, Rheumatrex can cause liver toxicity, while Sandimmune can impair kidney function.

      In recent years, mycophenolate mofetil (Cellcept) has been used as an effective medication for lupus, particularly when it associated with kidney disease. Cellcept has been helpful in reversing active lupus kidney disease (lupus renal disease) and in maintaining remission after it is established. It’s lower side effect profile has advantage over traditional immune suppression medications.

      In SLE patients with serious brain or kidney disease, plasmapheresis is sometimes used to remove antibodies and other immune substances from the blood to suppress immunity. Some SLE patients can develop seriously low platelet levels, thereby increasing the risk of excessive and spontaneous bleeding. Since the spleen is believed to be the major site of platelet destruction, surgical removal of the spleen is sometimes performed to improve platelet levels. Other treatments have included plasmapheresis and the use of male hormones. Plasmapheresis has also been used to remove proteins (cryoglobulins) that can lead to vasculitis. Endstage kidney damage from SLE requires dialysis and/or a kidney transplant.

      Most recent research is indicating benefits of rituximab (Rituxan) in treating lupus. Rituximab is an intravenously infused antibody that suppresses a particular white blood cell, the B cell, by decreasing their number in the circulation. B cells have been found to play a central role in lupus activity, and when they are suppressed, the disease tends toward remission.

      At the 2007 national Rheumatology meeting, there was a paper presented suggesting that low dose dietary supplementation with omega-3 fish oils could help patients with lupus by decreasing disease activity and possibly decreasing heart disease risk.

  2. wingsovgrace

    Have you been diagnosed with drug induced Lupus ?
    !0 years ago began having problem with elevated blood pressure. Was treated with the usually prescribed meds. Within the past ten years I have had a variety of unusual and often preplexing symptoms that the doctors couldn’t find good answers for. Lots of guesses and lots of unsuccessful treatments and increased frustration and misery until recently. The diagnosis is drug induced Lupus and it is believed to be caused by my blood pressure meds. Bingo. The symptoms have developed over the same period I’ve been on the meds. My question is: Any known effective alternatives for Blood Pressure Control? Anyone else with Lupus have bizarre skin and hair folllicle issues? Any one know a reputable doctor in Kansas City Missouri to advise on alternative treatments? Any one know of a web site to purchase alternative B/P treatments that you or someone you know have had personal experience with? Are there suggestions for a great support website for Lupus?

    1. Healing Oneself

      Hi WIngsOfGrace

      Here are some ideas to heal the issue. Also learning about detoxifying the blood by doing colon and liver cleanses will change your health forever.

      Cause
      Food allergies (there is a 100 percent correlation between lupus and food allergies), rheumatoid arthritis, other connective tissue diseases, parasites, candidiasis, bowel problems, and digestive enzyme deficiencies can create symptoms that mimic or exacerbate SLE. Migraines, epilepsy, and psychoses must also be ruled out before a proper course of treatment can be decided upon.

      Both forms of lupus primarily strike young women (90% of cases) and young children.

      The drugs hydralazine, procainamide, and beta blockers can cause false-positive readings of SLE, and can also produce a lupus-like condition that disappears when the drugs are no longer taken. Birth control pills and environmental stresses can also exacerbate lupus symptoms.

      ——————————————————————————–

      Natural Cures

      Diet: Eat an organic, whole foods diet. Also avoid overeating and limit your intake of dairy, beef products, and polyunsaturated oils. Also screen for food allergies and avoid all foods to which you are allergic or sensitive. Increase your intake of vegetables, especially green, yellow, and orange, and consume non-farm-raised fish several times a week.

      Herbs: Supplementation with Swedish bitters with each meal can increase hydrochloric acid production. Also drink an infusion of nettle twice a day. Other useful herbs include echinacea, goldenseal, licorice, pau d`arco, and red clover

      Hydrotherapy: Hydrotherapy is the application of water, ice, steam and hot and cold temperatures to maintain and restore health. Treatments include full body immersion, steam baths, saunas, sitz baths, colonic irrigation and the application of hot and/or cold compresses. Hydrotherapy is effective for treating a wide range of conditions and can easily be used in the home as part of a self-care program. Many Naturopathic Physicians, Physical Therapists and Day Spas use Hydrotherapy as part of treatment.

      Hyperthermia: Hyperthermia involves artificially creating fever in the body for the purpose of boosting immune function. Hyperthermia can be a highly effective method of eliminating toxins and heavy metals, as well as infectious bacteria and viruses that cannot survive in elevated body temperatures.

      *Purified water is essential for any hydrotherapy or hyperthermia treatment. Remedies for Treating Chlorinated Bath Water offers clear instructions and recommendations.

      Juice Therapy: Drink the juice of carrot, celery, flaxseed oil, black currant oil, and garlic.

      Nutritional Supplementation: Hydrochloric acid (HCL) deficiency is common in people with lupus, therefore HCL supplements with each meal is advised. Other useful nutrients include vitamin A with beta carotene, vitamin C and bioflavonoids, vitamin B complex, vitamin B5, vitamin B6, vitamin B12, calcium, magnesium, selenium, zinc, essential fatty acids, proteolytic enzymes taken away from meals, digestive enzymes taken with meals, and the amino acids L-cysteine, L-methionine, and L-cystine.

      Topical Treatment: PABA cream applied topically can help ease symptoms.

      Best of health to you

    1. Olga

      Lupus can be quite a bugger to pin down. It can mimic a whole range of other diseases and sometimes takes years to diagnose. The symptoms are wide and varied as it affects the whole system: skin, muscles and skeleton, kidneys, blood, heart, lungs and brain.

      Based on symptoms a doctor may have a SUSPICION that it could be lupus, but only a blood test will confirm.

      I’m not going to go into detail about symptoms, diagnostics and treatment as SLE is a huge subject, as all auto immune illnesses are.

      Good luck!

  3. WolfeDCool

    Inflammation of the fatty layer under the skin of the skull?
    I have LUPUS SLE and BEHCET Syndrome. I get sudden lumps all around the skull and forehead which are very painful. To the extent that I cannot rest my head on a pillow. My Dr. said it is inflmmation of the fatty layer of skin and I would like to know what next? And what excatly causes it or how to treat it, if any treatment? Thank you.

    1. Scouttster

      I would say anytime that happens – grab some Vodka and Orange juice, and have a few drinks or more.. Get drunk!
      The reason it does that is because its a bacterial infection in your system and thats where it shows itself… Alcohol kills bacteria. So, start drinking and you will be able to tame and maybe completely eliminate it from your system.

  4. sistervoodoo2

    For those living with Lupus how beneficial do you find online Lupus support groups?
    I was diagnosed with Lupus (SLE) in 1999 and run a large on line support group. I am curious if those living with Lupus really find the support and understanding they need on line?

    1. ALT DOC

      Hi sister

      Here are some ideas to help you overcome your condition.

      Cause
      Food allergies (there is a 100 percent correlation between lupus and food allergies), rheumatoid arthritis, other connective tissue diseases, parasites, candidiasis, bowel problems, and digestive enzyme deficiencies can create symptoms that mimic or exacerbate SLE. Migraines, epilepsy, and psychoses must also be ruled out before a proper course of treatment can be decided upon.

      Both forms of lupus primarily strike young women (90% of cases) and young children.

      The drugs hydralazine, procainamide, and beta blockers can cause false-positive readings of SLE, and can also produce a lupus-like condition that disappears when the drugs are no longer taken. Birth control pills and environmental stresses can also exacerbate lupus symptoms.

      ——————————————————————————–

      Natural Cures

      Diet: Eat an organic, whole foods diet. Also avoid overeating and limit your intake of dairy, beef products, and polyunsaturated oils. Also screen for food allergies and avoid all foods to which you are allergic or sensitive. Increase your intake of vegetables, especially green, yellow, and orange, and consume non-farm-raised fish several times a week.

      Herbs: Supplementation with Swedish bitters with each meal can increase hydrochloric acid production. Also drink an infusion of nettle twice a day. Other useful herbs include echinacea, goldenseal, licorice, pau d`arco, and red clover

      Hydrotherapy: Hydrotherapy is the application of water, ice, steam and hot and cold temperatures to maintain and restore health. Treatments include full body immersion, steam baths, saunas, sitz baths, colonic irrigation and the application of hot and/or cold compresses. Hydrotherapy is effective for treating a wide range of conditions and can easily be used in the home as part of a self-care program. Many Naturopathic Physicians, Physical Therapists and Day Spas use Hydrotherapy as part of treatment. I suggest several at-home hydrotherapy treatments..
      Hyperthermia: Hyperthermia involves artificially creating fever in the body for the purpose of boosting immune function. Hyperthermia can be a highly effective method of eliminating toxins and heavy metals, as well as infectious bacteria and viruses that cannot survive in elevated body temperatures. I suggest several at-home hyperthermia treatments.
      *Purified water is essential for any hydrotherapy or hyperthermia treatment. Remedies for Treating Chlorinated Bath Water offers clear instructions and recommendations.

      Juice Therapy: Drink the juice of carrot, celery, flaxseed oil, black currant oil, and garlic.

      Nutritional Supplementation: Hydrochloric acid (HCL) deficiency is common in people with lupus, therefore HCL supplements with each meal is advised. Other useful nutrients include vitamin A with beta carotene, vitamin C and bioflavonoids, vitamin B complex, vitamin B5, vitamin B6, vitamin B12, calcium, magnesium, selenium, zinc, essential fatty acids, proteolytic enzymes taken away from meals, digestive enzymes taken with meals, and the amino acids L-cysteine, L-methionine, and L-cystine.

      Topical Treatment: PABA cream applied topically can help ease symptoms.

      Alternative Professional Care
      If your symptoms persist despite the above measures, seek the help of a qualified health professional. The following professional care therapies have all been shown to be useful for treating Lupus: Acupuncture, Biofeedback Training, Bodywork, Cell Therapy, Chelation Therapy, Detoxification Therapy, Environmental Medicine, Enzyme Therapy, Guided Imagery, Homeopathy, Juice Therapy, Light Therapy, Magnetic Field Therapy, Natural Hormone Replacement Therapy, Naturopathic Medicine, Oxygen Therapy, Qigong, Rolfing, and Traditional Chinese Medicine

      Best of health to you

      Cheers

  5. Omega

    This is a toughy. Are their any natural cures for Lupus DLE and SLE? ?
    Lupus is an Autoimmune disease that triggers inflammation of tissue, joints and organs. Most Orthodox and conventional doctors say their isn’t a cure. However it has been suggested that Omega 3 acids help inflammation. Is their any other suggestions for this disease without having to rely on pharmaceutical drugs? Is there a cure?

  6. Unknown

    What are some of the medical treatments for lupus? How do people die from lupus do their organs sweal in?
    the body how does it happen and what are some of the treatments for lupus?

  7. Sanjay K

    Do Homeopathy has proper medicine for SLE or any other Alternatives mediums other than Allopathy?
    Is HomeoPathy treats SLE Disease stright away. If it has what is the treatment? Is it proven and if it is proven what is the proff? Is there any alternative medicines other than Allopathy for this treatment. Here SLE Refers: Systemic lupus erythematosus disease

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