Lupus Nephritis Treatment In India At Affordable Cost-Nephrology India

Author: Pankaj Nagpal

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Lupus Nephritis Treatment In India

 

What is lupus nephritis ?

Lupus nephritis is an inflammation of the kidney caused by systemic lupus erythematosus (SLE), a disease of the immune system. SLE typically causes harm to the skin, joints, kidneys, and brain.

The causes of SLE are unknown. Many factors may play a role, including : –

  • gendera€”SLE is more common in women than men
  • hereditya€”a gene passed down by a parent
  • infections
  • viruses
  • environmental causes…

 

What are the symptoms of lupus nephritis ?

Lupus nephritis may cause weight gain, high blood pressure, dark urine, or swelling around the eyes, legs, ankles, or fingers. However, some people with SLE have no overt symptoms of kidney disease, which must be diagnosed by blood and urine tests…..

 

How is lupus nephritis diagnosed ?

Diagnosis may require urine and blood tests as well as a kidney biopsy.

Urine test : – Blood or protein in the urine is a sign of kidney damage….

 

Blood test : – The kidneys remove waste materials like creatinine and urea from the blood. If the blood contains high levels of these substances, kidney function is declining. Your doctor should estimate your glomerular filtration rate based on your creatinine score….

 

Kidney biopsy : – A biopsy is a procedure to obtain a tissue sample for examination with a microscope. To obtain a sample of your kidney tissue, your doctor will insert a long needle through the skin. Examining the tissue with a microscope can confirm the diagnosis of lupus nephritis and help to determine how far the disease has progressed….

 

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2 thoughts on “Systemic Lupus Erythematosus Nephritis

  1. tmang0502

    pls react on this journal… your reaction would be a great help…thanks God Bless?
    ‘Multi-target’ Immune Therapy Improves Outcomes Of Severe Lupus Nephritis
    ScienceDaily (July 7, 2008) — A new treatment using a combination of drugs targeting different parts of the immune system improves the recovery rate for patients with severe lupus involving the kidneys, according to a new report.
    “In our study, multi-target therapy is shown to be superior to traditional therapy for inducing complete remission of class V+IV lupus nephritis, with few side effects,” comments Dr. Lei-Shi Li of the Research Institute of Nephrology of Jinling Hospital, Nanjing University School of Medicine in Nanjing,China.
    The study included 40 patients with severe lupus nephritis. Lupus nephritis is inflammation of the kidneys occurring in patients with the immune system disease systemic lupus erythematosus (SLE). All patients had “class V+IV” disease, meaning widespread inflammation and decreasing function of the kidneys. “This is a severe form of lupus nephritis that is traditionally treated with a single immunosuppressant drug, but the efficacy is very poor,” says Dr. Li. “We considered that, since the impact of severe SLE on the kidney involves various parts of the immune system, it is necessary to treat the different immune targets with a combination of immunosuppressant drugs.”
    One group of patients received this “multi-target” therapy, consisting of the immunosuppressant drugs tacrolimus and mycophenolate mofetil–commonly used as anti-rejection drugs in transplant patients–plus a steroid. The other group received standard treatment with a single immunosuppressant drug (cyclophosphamide).
    The complete remission rate, with recovery of normal kidney function, was about four times higher among patients receiving the three-drug combination. “For patients receiving multi-target therapy, the complete remission rate reached 65 percent at nine months, versus only 15 percent under traditional therapy,” says Dr. Li.
    Some patients in both groups had partial remission, with some return of kidney function. Overall, 95 percent of patients in the multi-target therapy group had partial or complete remission, compared to 55 percent with single-drug therapy. The rate of most adverse effects was also lower with multi-target therapy.
    Systemic lupus erythematosus is an autoimmune disorder, in which the immune system attacks healthy organs and tissues. By reducing immune system activity, treatment with immunosuppressant drugs has improved most outcomes for patients with SLE. However, class V+IV lupus nephritis continues to be a major problem–it has a poor response to traditional treatments and can lead to permanent kidney damage. “The prognosis is very poor, so it is important for us to develop a new regimen for the treatment of this type of lupus nephritis,” says Dr. Li.
    Using a combination of drugs that affect different immune targets, multi-target therapy improves the chances of remission for patients with severe lupus nephritis. “The therapeutic effect of our multi-target therapy is apparently superior to traditional therapy for inducing complete remission of Class V+IV lupus nephritis, and also bears good tolerance under relatively lower dosages,” Dr. Li adds.
    The authors stress that their study is only preliminary. The study includes a small group of patients from a single hospital, with a relatively short follow-up time. Larger randomized trials with longer follow-up are required.

    1. George S

      ok, a journal on lupus

      intersting if your an immunologist or for this type of lupus a nephrologist or just interested in lupus

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