” Systemic Lupus Erythematosus “( referred to as SLE) is a system for autoimmune diseases , causes and rheumatoid arthritis, Ankylosing spondylitis is similar to patientsImbalance in the immune system , resulting in excessive abnormal antibodies, and their cells mistaken for the enemy to attack . This disease can affect many organs and tissues of the body , causing inflammation and a variety of serious complications . Such as lack of governance, lupus affects the kidneys , heart, lungs and nervous system , resulting in a variety of serious complications such as nephritis, myocarditis, pleural effusion , encephalitis , can lead toThyroidOrgan failure and even death.

Had an approximately 40 -year-old man suffering from lung cancer ,Physical examinationAdmitted to hospital with fever, abdominal rash , vomiting and bowel movements a week with a trickle , later proved to have sepsis . Test of her stool samples with Strongyloides worms . The man lived 70 years in Vietnam for a long time , then moved to Hong Kong , estimated that he was infected in Vietnam . Strongyloides worms lurking in his body about 30 years , may be bred dozens or even hundreds . If the Strongyloides worms too many will lead to pulmonary or intestinal bleeding , or pneumonia, the disease may induce asthma . Strongyloides worms can be found in the intestines of bacteria such as E. coli into the blood , leading to sepsis , severe life-threatening . Strongyloides worms appear mainly in Southeast Asia , people traveling abroad not to play barefoot in the countryside , to protect us from infection .

Eyes not only window to the soul , a person can predict whether there will be little futureStroke. Centre for Eye Research Australia, found that health care workers , such as the health of abnormal retinal blood vessels , the brain appears next small increased risk of stroke two to three times. Small stroke (mini-Stroke) , also known as silent stroke , vascular occlusion affecting the brain due to blood supply , so a small part of the hypoxic brain damage , can cause mild cognitive problems, but patients may not detect abnormal physical activity , diagnosis is also difficult. But the small increase in the future there will be a fatal stroke, stroke or even the risk of dementia . Researchers to determine if the retinal vascular abnormalities , the small risk of stroke compared with no retinopathy two to three times higher , such as the early members of the public from the health of the eye abnormalities found atSituation , you can take early preventive measures .

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Source: http://www.sooperarticles.com/health-fitness-articles/thyroid-organ-127364.html


systemic lupus nephritis prognosis

2 thoughts on “Systemic Lupus Nephritis Prognosis

  1. tmang0502

    pls react on this journal… your reaction would be a great help…thanks God Bless?
    ‘Multi-target’ Immune Therapy Improves Outcomes Of Severe Lupus Nephritis
    ScienceDaily (July 7, 2008) — A new treatment using a combination of drugs targeting different parts of the immune system improves the recovery rate for patients with severe lupus involving the kidneys, according to a new report.
    “In our study, multi-target therapy is shown to be superior to traditional therapy for inducing complete remission of class V+IV lupus nephritis, with few side effects,” comments Dr. Lei-Shi Li of the Research Institute of Nephrology of Jinling Hospital, Nanjing University School of Medicine in Nanjing,China.
    The study included 40 patients with severe lupus nephritis. Lupus nephritis is inflammation of the kidneys occurring in patients with the immune system disease systemic lupus erythematosus (SLE). All patients had “class V+IV” disease, meaning widespread inflammation and decreasing function of the kidneys. “This is a severe form of lupus nephritis that is traditionally treated with a single immunosuppressant drug, but the efficacy is very poor,” says Dr. Li. “We considered that, since the impact of severe SLE on the kidney involves various parts of the immune system, it is necessary to treat the different immune targets with a combination of immunosuppressant drugs.”
    One group of patients received this “multi-target” therapy, consisting of the immunosuppressant drugs tacrolimus and mycophenolate mofetil–commonly used as anti-rejection drugs in transplant patients–plus a steroid. The other group received standard treatment with a single immunosuppressant drug (cyclophosphamide).
    The complete remission rate, with recovery of normal kidney function, was about four times higher among patients receiving the three-drug combination. “For patients receiving multi-target therapy, the complete remission rate reached 65 percent at nine months, versus only 15 percent under traditional therapy,” says Dr. Li.
    Some patients in both groups had partial remission, with some return of kidney function. Overall, 95 percent of patients in the multi-target therapy group had partial or complete remission, compared to 55 percent with single-drug therapy. The rate of most adverse effects was also lower with multi-target therapy.
    Systemic lupus erythematosus is an autoimmune disorder, in which the immune system attacks healthy organs and tissues. By reducing immune system activity, treatment with immunosuppressant drugs has improved most outcomes for patients with SLE. However, class V+IV lupus nephritis continues to be a major problem–it has a poor response to traditional treatments and can lead to permanent kidney damage. “The prognosis is very poor, so it is important for us to develop a new regimen for the treatment of this type of lupus nephritis,” says Dr. Li.
    Using a combination of drugs that affect different immune targets, multi-target therapy improves the chances of remission for patients with severe lupus nephritis. “The therapeutic effect of our multi-target therapy is apparently superior to traditional therapy for inducing complete remission of Class V+IV lupus nephritis, and also bears good tolerance under relatively lower dosages,” Dr. Li adds.
    The authors stress that their study is only preliminary. The study includes a small group of patients from a single hospital, with a relatively short follow-up time. Larger randomized trials with longer follow-up are required.

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